Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 6/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 6/20 | 0.47 |
| ▸ | HPGD | P15428 | 5/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | SIRT1 | Q96EB6 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | NTSR1 | P30989 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.41 |
| ▸ | BACE1 | P56817 | 1/20 | 0.41 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2740288 | 0.91 | MEN1 (0.47) | MEN1KMT2AALDH1A1KDM4EMAPK1 | |
| SCHEMBL14608036 | 0.86 | MEN1 (0.60) | MEN1KMT2AALDH1A1KDM4EMAPK1 | |
| SCHEMBL2739954 | 0.79 | MEN1 (0.56) | MEN1KMT2AALDH1A1KDM4EMAPK1 | |
| SCHEMBL14614790 | 0.78 | MEN1 (0.39) | MEN1KMT2AALDH1A1KDM4EMAPK1 | |
| SCHEMBL2740289 | 0.77 | SIRT1 (0.54) | MEN1KMT2AALDH1A1KDM4EMAPK1 | |
| SCHEMBL13470801 | 0.77 | MEN1 (0.53) | MEN1KMT2AALDH1A1KDM4EMAPK1 | |
| SCHEMBL2739953 | 0.77 | PDCD1 (0.51) | MEN1KMT2AALDH1A1KDM4EMAPK1 | |
| SCHEMBL14618011 | 0.76 | CACNA1G (0.40) | MEN1KMT2AALDH1A1KDM4EMAPK1 | |
| SCHEMBL30866246 | 0.75 | NPC1 (0.58) | MEN1KMT2AALDH1A1KDM4EMAPT | |
| SCHEMBL26606466 | 0.75 | NPC1 (0.58) | MEN1KMT2AALDH1A1KDM4EMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007019416-A1 | BENZIMIDAZOLE DERIVATIVES AS SIRTUIN MODULATORS | SIRTRIS PHARMACEUTICALS, INC. (US) | 2007-02-15 | — | — | WO | disclosed |