Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 6/20 | 0.32 |
| ▸ | HSP90AB1 | P08238 | 3/20 | 0.32 |
| ▸ | LMNA | P02545 | 2/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | BRD9 | Q9H8M2 | 2/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1148578 | 0.93 | HSP90AA1 (0.36) | HSP90AA1HSP90AB1LMNAMAPTBRD9 | |
| SCHEMBL14456183 | 0.85 | LMNA (0.34) | LMNAMAPTBRD9ALDH1A1MEN1 | |
| SCHEMBL1148791 | 0.85 | HSP90AA1 (0.35) | HSP90AA1HSP90AB1LMNAMAPTBRD9 | |
| SCHEMBL1148714 | 0.84 | HSP90AA1 (0.36) | HSP90AA1HSP90AB1LMNAMAPTBRD9 | |
| SCHEMBL1147829 | 0.83 | HSP90AA1 (0.49) | HSP90AA1HSP90AB1 | |
| SCHEMBL1148403 | 0.83 | HSP90AA1 (0.33) | HSP90AA1HSP90AB1 | |
| SCHEMBL1147959 | 0.81 | HSP90AA1 (0.35) | HSP90AA1HSP90AB1BRD9MEN1KMT2A | |
| SCHEMBL1147973 | 0.81 | HSP90AA1 (0.36) | HSP90AA1HSP90AB1LMNAMAPTBRD9 | |
| SCHEMBL13108657 | 0.80 | CRHR1 (0.34) | HSP90AA1HSP90AB1MAPTBRD9MEN1 | |
| SCHEMBL1148760 | 0.79 | CYP3A4 (0.35) | HSP90AA1HSP90AB1LMNAMAPTBRD9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007021877-A1 | IMIDAZOLE COMPOUNDS THAT MODULATE HSP90 ACTIVITY | SYNTA PHARMACEUTICALS CORP. (US) | 2007-02-22 | — | — | WO | disclosed |