Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 1/20 | 0.43 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.43 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.43 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.41 |
| ▸ | DRD2 | P14416 | 2/20 | 0.41 |
| ▸ | HTR2A | P28223 | 2/20 | 0.41 |
| ▸ | HTR2C | P28335 | 2/20 | 0.41 |
| ▸ | HTR2B | P41595 | 2/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.38 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.37 |
| ▸ | AXL | P30530 | 2/20 | 0.36 |
| ▸ | MERTK | Q12866 | 2/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5578544 | 0.91 | SIGMAR1 (0.47) | OPRM1OPRK1OPRL1SIGMAR1DRD2 | |
| SCHEMBL5578473 | 0.90 | OPRM1 (0.44) | OPRM1OPRK1OPRL1SIGMAR1DRD2 | |
| SCHEMBL5578998 | 0.88 | OPRM1 (0.44) | OPRM1OPRK1OPRL1HDAC1HDAC6 | |
| SCHEMBL5579018 | 0.87 | OPRM1 (0.43) | OPRM1OPRK1OPRL1SIGMAR1DRD2 | |
| SCHEMBL5579306 | 0.87 | HDAC1 (0.48) | OPRM1OPRK1OPRL1SIGMAR1DRD2 | |
| SCHEMBL5579232 | 0.87 | AXL (0.42) | OPRM1OPRK1OPRL1SIGMAR1DRD2 | |
| SCHEMBL5578622 | 0.85 | OPRM1 (0.43) | OPRM1OPRK1OPRL1SIGMAR1DRD2 | |
| SCHEMBL5579089 | 0.85 | TSHR (0.46) | OPRM1OPRK1OPRL1 | |
| SCHEMBL5578717 | 0.85 | OPRM1 (0.40) | OPRM1OPRK1OPRL1SIGMAR1DRD2 | |
| SCHEMBL5578593 | 0.85 | KDM2B (0.48) | OPRM1OPRK1OPRL1DRD2HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005063745-A9 | NOVEL SPIROINDOLINE OR SPIROISOQUINOLINE COMPOUNDS, METHODS OF USE AND COMPOSITIONS THEREOF | ARENA PHARM INC (US) | 2007-02-01 | — | — | WO | disclosed |