Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP1 | P03956 | 20/20 | 0.81 |
| ▸ | MMP13 | P45452 | 19/20 | 0.81 |
| ▸ | ADAM17 | P78536 | 15/20 | 0.81 |
| ▸ | MMP3 | P08254 | 8/20 | 0.74 |
| ▸ | MMP2 | P08253 | 7/20 | 0.74 |
| ▸ | MMP7 | P09237 | 5/20 | 0.74 |
| ▸ | MMP9 | P14780 | 7/20 | 0.72 |
| ▸ | MMP8 | P22894 | 3/20 | 0.72 |
| ▸ | ADAM10 | O14672 | 2/20 | 0.70 |
| ▸ | ADAM9 | Q13443 | 2/20 | 0.70 |
| ▸ | MMP14 | P50281 | 2/20 | 0.68 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3947996 | 0.88 | MMP1 (0.83) | MMP1MMP13ADAM17MMP3MMP2 | |
| SCHEMBL8394315 | 0.88 | MMP1 (0.62) | MMP1MMP13ADAM17MMP3MMP2 | |
| SCHEMBL3945461 | 0.86 | MMP1 (0.82) | MMP1MMP13ADAM17MMP3MMP2 | |
| SCHEMBL6383433 | 0.86 | MMP1 (0.77) | MMP1MMP13ADAM17MMP3MMP2 | |
| SCHEMBL7075595 | 0.85 | MMP1 (0.75) | MMP1MMP13ADAM17MMP3MMP2 | |
| SCHEMBL7351911 | 0.84 | MMP1 (1.00) | MMP1MMP13ADAM17MMP3MMP2 | |
| SCHEMBL3948482 | 0.84 | MMP1 (1.00) | MMP1MMP13ADAM17MMP3MMP2 | |
| SCHEMBL8033898 | 0.84 | MMP1 (0.80) | MMP1MMP13ADAM17MMP3MMP2 | |
| SCHEMBL2358255 | 0.83 | ADAM17 (1.00) | MMP1MMP13ADAM17MMP3MMP2 | |
| SCHEMBL3942486 | 0.83 | ADAM17 (1.00) | MMP1MMP13ADAM17MMP3MMP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7179911-B2 | coupling a silyl ester of (3S)-2,2-dimethyl-tetrahydro-2H-1,4-thiazine-3-carboxylic acid with 6,4-[4-(chlorosulfonyl)phenoxy]-2-butynyl acetate, hydrolyzing the silyl ester | WYETH (US) | 2007-02-20 | — | — | US | disclosed |