Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FABP4 | P15090 | 1/20 | 0.47 |
| ▸ | BRAF | P15056 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | SLC40A1 | Q9NP59 | 1/20 | 0.43 |
| ▸ | METAP2 | P50579 | 3/20 | 0.43 |
| ▸ | METAP1 | P53582 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | EIF2AK4 | Q9P2K8 | 1/20 | 0.42 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.42 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.42 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.42 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | IKBKB | O14920 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | F2 | P00734 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1492020 | 0.94 | FABP4 (0.48) | FABP4BRAFKMT2ASLC40A1METAP2 | |
| SCHEMBL1492012 | 0.88 | SLC40A1 (0.52) | KMT2ASLC40A1METAP2ALDH1A1GAA | |
| SCHEMBL1462153 | 0.88 | SLC40A1 (0.52) | KMT2ASLC40A1METAP2ALDH1A1GAA | |
| SCHEMBL1462085 | 0.83 | FABP4 (0.59) | FABP4BRAFKMT2ASLC40A1METAP2 | |
| SCHEMBL14578983 | 0.81 | BRAF (0.49) | FABP4BRAFCYP2C19 | |
| SCHEMBL3020511 | 0.81 | CYP3A4 (0.55) | BRAF | |
| SCHEMBL3026664 | 0.80 | HSD17B2 (0.50) | KMT2AALDH1A1CYP2C19 | |
| SCHEMBL3017378 | 0.80 | CYP2C19 (0.60) | FABP4KMT2AMETAP2ALDH1A1CYP2C19 | |
| SCHEMBL3022486 | 0.79 | FABP4 (0.50) | FABP4BRAFALDH1A1 | |
| SCHEMBL3029913 | 0.79 | CYP3A4 (0.56) | BRAFSLC40A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2493865-A2 | RAF INHIBITOR COMPOUNDS AND METHODS OF USE THEREOF | Array Biopharma, Inc. (US) | 2012-09-05 | — | — | EP | disclosed |
| WO-2011025938-A2 | RAF INHIBITOR COMPOUNDS AND METHODS OF USE THEREOF | ARRAY BIOPHARMA INC. (US) | 2011-03-03 | — | — | WO | disclosed |