Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 3/20 | 0.51 |
| ▸ | AURKA | O14965 | 5/20 | 0.50 |
| ▸ | SYK | P43405 | 3/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | JAK2 | O60674 | 2/20 | 0.48 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.48 |
| ▸ | EGFR | P00533 | 3/20 | 0.48 |
| ▸ | CDK2 | P24941 | 2/20 | 0.48 |
| ▸ | STK17A | Q9UEE5 | 2/20 | 0.48 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.48 |
| ▸ | NTRK2 | Q16620 | 2/20 | 0.48 |
| ▸ | BTK | Q06187 | 2/20 | 0.48 |
| ▸ | CDC7 | O00311 | 1/20 | 0.48 |
| ▸ | PLK4 | O00444 | 1/20 | 0.48 |
| ▸ | DCLK1 | O15075 | 1/20 | 0.48 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.48 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.48 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.48 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.48 |
| ▸ | PAK4 | O96013 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL653706 | 0.74 | SYK (0.72) | JAK3AURKASYKALDH1A1JAK2 | |
| SCHEMBL19675784 | 0.74 | MERTK (0.54) | AURKASYKALDH1A1JAK2HDAC1 | |
| SCHEMBL28504300 | 0.74 | JAK3 (0.63) | JAK3AURKASYKJAK2HDAC1 | |
| SCHEMBL12278793 | 0.73 | EPHB4 (0.49) | JAK3AURKASYKJAK2HDAC1 | |
| SCHEMBL19675865 | 0.73 | AURKA (0.66) | JAK3AURKASYKJAK2HDAC1 | |
| SCHEMBL2911248 | 0.72 | MAPT (0.54) | JAK3AURKASYKALDH1A1JAK2 | |
| SCHEMBL18165623 | 0.72 | EGFR (0.82) | JAK3JAK2EGFRBTKLYN | |
| SCHEMBL19654299 | 0.71 | BRD4 (0.67) | JAK3AURKASYKALDH1A1JAK2 | |
| SCHEMBL19654300 | 0.71 | BRD4 (0.67) | JAK3AURKASYKALDH1A1JAK2 | |
| SCHEMBL20288209 | 0.70 | JAK2 (0.75) | JAK3AURKASYKJAK2HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007008541-A2 | CELLULAR CHOLESTEROL ABSORPTION MODIFIERS | KALYPSYS, INC. (US) | 2007-01-18 | — | — | WO | disclosed |