Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | ASPH | Q12797 | 1/20 | 0.44 |
| ▸ | KDM8 | Q8N371 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | EGFR | P00533 | 1/20 | 0.35 |
| ▸ | ATR | Q13535 | 1/20 | 0.35 |
| ▸ | KDM5A | P29375 | 1/20 | 0.34 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.33 |
| ▸ | KMO | O15229 | 1/20 | 0.33 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.33 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.32 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29418893 | 0.84 | KDM4E (0.63) | KDM4EASPHKDM8LMNASMN1; SMN2 | |
| SCHEMBL473869 | 0.84 | KDM4E (0.63) | KDM4EASPHKDM8LMNASMN1; SMN2 | |
| SCHEMBL23326783 | 0.82 | KDM4E (0.43) | KDM4EASPHKDM8LMNASMN1; SMN2 | |
| SCHEMBL27096669 | 0.82 | KDM4E (0.43) | KDM4EASPHKDM8LMNASMN1; SMN2 | |
| SCHEMBL22466559 | 0.82 | KDM4E (0.46) | KDM4EASPHKDM8LMNASMN1; SMN2 | |
| SCHEMBL27189436 | 0.82 | KDM4E (0.46) | KDM4EASPHKDM8LMNASMN1; SMN2 | |
| SCHEMBL27471803 | 0.79 | SMN1; SMN2 (0.44) | KDM4EASPHKDM8LMNASMN1; SMN2 | |
| SCHEMBL1031057 | 0.79 | SMN1; SMN2 (0.44) | KDM4EASPHKDM8LMNASMN1; SMN2 | |
| SCHEMBL29209717 | 0.78 | KDM4E (0.43) | KDM4EASPHKDM8SMN1; SMN2ALDH1A1 | |
| SCHEMBL30881744 | 0.78 | KDM4E (0.43) | KDM4EASPHKDM8SMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3897842-B1 | BICYCLIC DERIVATIVES | ELANCO TIERGESUNDHEIT AG (CH) | 2025-01-29 | — | — | EP | disclosed |
| CN-113490527-B | Bicyclic derivatives | 瑞士伊兰科动物保健有限公司 | 2024-10-25 | — | — | CN | disclosed |
| US-20220064159-A1 | BICYCLIC DERIVATIVES | ELANCO TIERGESUNDHEIT AG (CH) | 2022-03-03 | — | — | US | disclosed |
| EP-3897842-A1 | BICYCLIC DERIVATIVES | Elanco Tiergesundheit AG (CH) | 2021-10-27 | — | — | EP | disclosed |
| CN-113490527-A | Bicyclic derivatives | 瑞士伊兰科动物保健有限公司 | 2021-10-08 | — | — | CN | disclosed |
| WO-2020131631-A1 | BICYCLIC DERIVATIVES | ELANCO TIERGESUNDHEIT AG (CH) | 2020-06-25 | — | — | WO | disclosed |
| US-20130018033-A1 | RAF INHIBITOR COMPOUNDS AND METHODS OF USE THEREOF | ARRAY BIOPHARMA INC. (US) | 2013-01-17 | — | — | US | disclosed |
| EP-2493865-A2 | RAF INHIBITOR COMPOUNDS AND METHODS OF USE THEREOF | Array Biopharma, Inc. (US) | 2012-09-05 | — | — | EP | disclosed |
| WO-2011025938-A2 | RAF INHIBITOR COMPOUNDS AND METHODS OF USE THEREOF | ARRAY BIOPHARMA INC. (US) | 2011-03-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220064159-A1 | BICYCLIC DERIVATIVES | FABP3, CYCS, PIGS | KDM4E 2222/4885ASPH 3442/4885KDM8 2797/4885 |
| US-20130018033-A1 | RAF INHIBITOR COMPOUNDS AND METHODS OF USE THEREOF | BRAF, RAF1, ARAF | KDM4E 3645/4885ASPH 1825/4885KDM8 2347/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.