Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGFBR1 | P36897 | 6/20 | 0.46 |
| ▸ | TRIM33 | Q9UPN9 | 5/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.42 |
| ▸ | TRIM24 | O15164 | 2/20 | 0.42 |
| ▸ | RIPK2 | O43353 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | EPHB3 | P54753 | 1/20 | 0.40 |
| ▸ | HTR6 | P50406 | 1/20 | 0.39 |
| ▸ | CLK1 | P49759 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | GLA | P06280 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14427931 | 0.85 | TGFBR1 (0.46) | TGFBR1TRIM33MAPK1TRIM24RIPK2 | |
| SCHEMBL3490961 | 0.78 | MAPK1 (0.45) | TGFBR1TRIM33MAPK1TRIM24RIPK2 | |
| SCHEMBL3033347 | 0.78 | MAPK1 (0.45) | TGFBR1TRIM33MAPK1TRIM24RIPK2 | |
| SCHEMBL24997431 | 0.76 | ALDH1A1 (0.45) | TGFBR1TRIM33MAPK1TRIM24RIPK2 | |
| SCHEMBL1355620 | 0.75 | ADORA2A (0.62) | TGFBR1MAPK1KDM4EEPHB3NPC1 | |
| SCHEMBL15231746 | 0.74 | BRD4 (0.45) | TGFBR1TRIM33MAPK1TRIM24RIPK2 | |
| SCHEMBL3490519 | 0.73 | FYN (0.55) | TRIM33TRIM24RIPK2KDM4ECLK1 | |
| SCHEMBL25148814 | 0.73 | CHEK1 (0.46) | TGFBR1RIPK2KDM4ENPC1ALDH1A1 | |
| SCHEMBL15639434 | 0.72 | PIK3CA (0.45) | TGFBR1KDM4EEPHB3CLK1NPC1 | |
| SCHEMBL3491081 | 0.72 | TGFBR1 (0.46) | TGFBR1RIPK2KDM4ENPC1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1353905-B1 | PIPERIDINE/PIPERAZINE-TYPE INHIBITORS OF P38 KINASE | SCIOS INC (US) | 2007-01-10 | — | — | EP | disclosed |