Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACACB | O00763 | 12/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | ACACA | Q13085 | 2/20 | 0.38 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.37 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.37 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.37 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.37 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.37 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.37 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.37 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.37 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.37 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1815455 | 0.74 | ACACA (0.65) | ACACAKMT2A | |
| SCHEMBL742628 | 0.67 | ACACB (0.51) | ACACBACACAHDAC3HDAC4HDAC1 | |
| SCHEMBL741034 | 0.66 | ACACB (0.49) | ACACBACACAHDAC3HDAC4HDAC1 | |
| SCHEMBL15163607 | 0.66 | ACACB (0.50) | ACACBACACAHDAC3HDAC4HDAC1 | |
| SCHEMBL743841 | 0.66 | ACACB (0.50) | ACACBACACAHDAC3HDAC4HDAC1 | |
| SCHEMBL730728 | 0.65 | ACACB (0.51) | ACACBACACAHDAC3HDAC4HDAC1 | |
| SCHEMBL731139 | 0.65 | ACACB (0.50) | ACACBACACAHDAC3HDAC4HDAC1 | |
| SCHEMBL731138 | 0.65 | ACACB (0.50) | ACACBACACAHDAC3HDAC4HDAC1 | |
| SCHEMBL13069179 | 0.65 | L3MBTL1 (0.62) | ACACBL3MBTL1ACACAKMT2A | |
| SCHEMBL15163608 | 0.65 | ACACB (0.50) | ACACBACACAHDAC3HDAC4HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007011809-A1 | SPIROCHROMANONE DERIVATIVES AS ACETYL COENZYME A CARBOXYLASE (ACC) INHIBITORS | MERCK & CO., INC. (US) | 2007-01-25 | — | — | WO | disclosed |