Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN11 | Q06124 | 6/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | JAK2 | O60674 | 1/20 | 0.51 |
| ▸ | JAK1 | P23458 | 1/20 | 0.51 |
| ▸ | TYK2 | P29597 | 1/20 | 0.51 |
| ▸ | JAK3 | P52333 | 1/20 | 0.51 |
| ▸ | PIK3CA | P42336 | 7/20 | 0.47 |
| ▸ | PIK3R1 | P27986 | 5/20 | 0.47 |
| ▸ | MTOR | P42345 | 3/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.47 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | ATR | Q13535 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12091894 | 0.84 | PIK3CA (0.56) | PIK3CAPIK3R1MTORPIK3CDPIK3CB | |
| SCHEMBL245978 | 0.83 | PTPN11 (0.69) | PTPN11KMT2APIK3CAKDM4EALDH1A1 | |
| SCHEMBL14590423 | 0.82 | PTPN11 (0.46) | PTPN11KMT2AJAK2JAK1TYK2 | |
| SCHEMBL244184 | 0.79 | KDM4E (0.66) | PTPN11KMT2APIK3CAKDM4EALDH1A1 | |
| SCHEMBL14625957 | 0.76 | PTPN11 (0.57) | PTPN11KMT2APIK3CAKDM4EALDH1A1 | |
| SCHEMBL21121002 | 0.74 | KMT2A (0.58) | PTPN11KMT2APIK3CAPIK3R1MTOR | |
| SCHEMBL1013949 | 0.72 | POLB (0.59) | PTPN11KMT2APIK3CAPIK3R1MTOR | |
| SCHEMBL24196192 | 0.71 | KDM4E (0.69) | PTPN11KMT2APIK3CAPIK3R1MTOR | |
| SCHEMBL26647400 | 0.71 | PIK3CA (0.56) | PTPN11KMT2APIK3CAPIK3R1MTOR | |
| SCHEMBL245017 | 0.71 | ALDH1A1 (0.63) | PTPN11KMT2APIK3CAPIK3R1MTOR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7160877-B2 | Aliphatic nitrogen-containing 5-membered ring compound | TANABE SEIYAKU CO., LTD. (JP) | 2007-01-09 | — | — | US | disclosed |