Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 14/20 | 0.38 |
| ▸ | NR1H3 | Q13133 | 12/20 | 0.38 |
| ▸ | RXRA | P19793 | 1/20 | 0.35 |
| ▸ | PTPN1 | P18031 | 3/20 | 0.35 |
| ▸ | CTSL | P07711 | 1/20 | 0.35 |
| ▸ | CTSB | P07858 | 1/20 | 0.35 |
| ▸ | CTSS | P25774 | 1/20 | 0.35 |
| ▸ | CTSK | P43235 | 1/20 | 0.35 |
| ▸ | KIF11 | P52732 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14626940 | 0.88 | KIF11 (0.34) | NR1H2PTPN1KIF11 | |
| SCHEMBL5404860 | 0.83 | PTPN1 (0.51) | NR1H2NR1H3PTPN1 | |
| SCHEMBL14626826 | 0.80 | TSHR (0.39) | RXRAPTPN1 | |
| SCHEMBL5413494 | 0.79 | PTPN1 (0.40) | NR1H2NR1H3RXRAPTPN1 | |
| SCHEMBL14626942 | 0.79 | PTPN1 (0.34) | RXRAPTPN1 | |
| SCHEMBL14626825 | 0.76 | ALOX5 (0.34) | PTPN1 | |
| SCHEMBL14627016 | 0.74 | NOTUM (0.50) | — | |
| SCHEMBL14627094 | 0.74 | FFAR1 (0.41) | — | |
| SCHEMBL5404861 | 0.73 | NR1H2 (0.39) | NR1H2NR1H3RXRACTSK | |
| SCHEMBL14627021 | 0.72 | FFAR4 (0.33) | PTPN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7163932-B2 | Aryldifluoromethylphosphonic acids for treatment of diabetes | MERCK FROSST CANADA & CO. (CA) | 2007-01-16 | — | — | US | disclosed |