Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 1/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.52 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.52 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.52 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.52 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.47 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.43 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.42 |
| ▸ | PTGFR | P43088 | 1/20 | 0.42 |
| ▸ | PTGER3 | P43115 | 1/20 | 0.42 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.42 |
| ▸ | PTGIR | P43119 | 1/20 | 0.42 |
| ▸ | PTGDR | Q13258 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1048274 | 0.96 | CYP1A2 (0.49) | CYP1A2CYP3A4CYP2D6CYP2C9TSHR | |
| SCHEMBL1048275 | 0.96 | CYP1A2 (0.49) | CYP1A2CYP3A4CYP2D6CYP2C9TSHR | |
| SCHEMBL1051004 | 0.92 | CYP1A2 (0.57) | CYP1A2CYP3A4CYP2D6CYP2C9TSHR | |
| SCHEMBL1051005 | 0.92 | CYP1A2 (0.57) | CYP1A2CYP3A4CYP2D6CYP2C9TSHR | |
| SCHEMBL1046826 | 0.92 | ENPP2 (0.54) | CYP1A2CYP3A4CYP2D6CYP2C9TSHR | |
| SCHEMBL1046825 | 0.92 | ENPP2 (0.54) | CYP1A2CYP3A4CYP2D6CYP2C9TSHR | |
| SCHEMBL14595167 | 0.90 | MEN1 (0.44) | CYP1A2CYP3A4CYP2D6CYP2C9TSHR | |
| SCHEMBL1049018 | 0.90 | ENPP2 (0.47) | CYP1A2CYP3A4CYP2D6CYP2C9TSHR | |
| SCHEMBL5317702 | 0.90 | ENPP2 (0.56) | CYP1A2CYP3A4CYP2D6CYP2C9TSHR | |
| SCHEMBL1049019 | 0.90 | ENPP2 (0.47) | CYP1A2CYP3A4CYP2D6CYP2C9TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070015771-A1 | Lonidamine analogs | THRESHOLD PHARMACEUTICALS, INC. (US) | 2007-01-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070015771-A1 | Lonidamine analogs | LONP1, LPXN, QDPR | CYP1A2 4551/4885CYP3A4 4009/4885CYP2D6 4125/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.