Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | HTT | P42858 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | NCOA1 | Q15788 | 2/20 | 0.33 |
| ▸ | NCOA3 | Q9Y6Q9 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | PPARG | P37231 | 1/20 | 0.33 |
| ▸ | NCOA2 | Q15596 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1460808 | 0.62 | MAOB (0.42) | ALDH1A1HTTMEN1KMT2AKDM4E | |
| SCHEMBL3787524 | 0.61 | HTT (0.55) | ALDH1A1HTTMEN1KMT2AKDM4E | |
| SCHEMBL9852518 | 0.60 | KDM4E (0.33) | ALDH1A1HTTKDM4ENCOA1NCOA3 | |
| SCHEMBL21672392 | 0.56 | MEN1 (0.36) | ALDH1A1HTTMEN1KMT2A | |
| SCHEMBL22911106 | 0.55 | MEN1 (0.42) | ALDH1A1HTTMEN1KMT2A | |
| SCHEMBL795326 | 0.49 | — | — | |
| SCHEMBL736971 | 0.48 | NUDT1 (0.50) | ALDH1A1HTTKDM4E | |
| SCHEMBL15760556 | 0.48 | PDE10A (0.38) | ALDH1A1HTTMEN1KMT2AKDM4E | |
| SCHEMBL19942300 | 0.48 | PDE10A (0.38) | ALDH1A1HTTKDM4EHPGD | |
| SCHEMBL1811759 | 0.48 | AXL (0.52) | ALDH1A1HTTKDM4ENCOA1NCOA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140045836-A1 | [1,2,4]TRIAZOLO[1,5-C]PYRIMIDINE DERIVATIVES AS HSP90 MODULATORS | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2014-02-13 | — | — | US | disclosed |
| US-8580783-B2 | [1,2,4]triazolo [1,5-c]pyrimidine derivatives as Hsp90 modulators | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2013-11-12 | — | — | US | disclosed |
| US-20120184546-A1 | [1,2,4]TRIAZOLO [1,5-C]PYRIMIDINE DERIVATIVES AS HSP90 MODULATORS | NERVIANO MEDICAL SCIENCES S.R.L (IT) | 2012-07-19 | — | — | US | disclosed |
| EP-2475665-A1 | [1,2,4]TRIAZOLO [1,5-c]PYRIMIDINE DERIVATIVES AS Hsup90 MODULATORS | Nerviano Medical Sciences S.r.l. (IT) | 2012-07-18 | — | — | EP | disclosed |
| WO-2011029775-A1 | [1,2,4]TRIAZOLO [1,5-c]PYRIMIDINE DERIVATIVES AS Hsup90 MODULATORS | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2011-03-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140045836-A1 | [1,2,4]TRIAZOLO[1,5-C]PYRIMIDINE DERIVATIVES AS HSP90 MODULATORS | HSP90AB1, HSP90AA1, HSP90AB2P | ALDH1A1 1300/4885HTT 34/4885MEN1 4673/4885 |
| US-20120184546-A1 | [1,2,4]TRIAZOLO [1,5-C]PYRIMIDINE DERIVATIVES AS HSP90 MODULATORS | HSP90AB1, HSP90AA1, HSP90AB2P | ALDH1A1 848/4885HTT 39/4885MEN1 4630/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.