Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 2/20 | 0.39 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.36 |
| ▸ | PARP1 | P09874 | 1/20 | 0.36 |
| ▸ | MTNR1A | P48039 | 3/20 | 0.35 |
| ▸ | MTNR1B | P49286 | 3/20 | 0.35 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.35 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.35 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.34 |
| ▸ | GALR3 | O60755 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14628611 | 0.88 | HTR2C (0.42) | HTR2CMAPKAPK2KDM4EALDH1A1MAPT | |
| SCHEMBL14628603 | 0.85 | ALDH1A1 (0.41) | MAPKAPK2KDM4EALDH1A1MAPTMTNR1A | |
| SCHEMBL14628605 | 0.83 | MAPKAPK2 (0.43) | HTR2CMAPKAPK2KDM4EALDH1A1MAPT | |
| SCHEMBL14628631 | 0.83 | HTR2C (0.42) | HTR2CMAPKAPK2KDM4EALDH1A1MAPT | |
| SCHEMBL14628604 | 0.74 | HTR2C (0.43) | HTR2CMAPKAPK2KDM4EALDH1A1MAPT | |
| SCHEMBL14628656 | 0.73 | MAPKAPK2 (0.45) | HTR2CMAPKAPK2KDM4EALDH1A1MAPT | |
| SCHEMBL14598623 | 0.73 | MAPKAPK2 (0.45) | HTR2CMAPKAPK2KDM4EALDH1A1MAPT | |
| SCHEMBL16585852 | 0.71 | MAPKAPK2 (0.43) | HTR2CMAPKAPK2KDM4EALDH1A1MAPT | |
| SCHEMBL14628607 | 0.71 | DDB1 (0.38) | MAPKAPK2KDM4EALDH1A1MAPTMTNR1A | |
| SCHEMBL14598613 | 0.69 | PLA2G2A (0.44) | MTNR1AMTNR1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7160909-B2 | Cyclopenta[b]indole derivatives as sPLA2 inhibitors | ELI LILLY AND COMPANY (US) | 2007-01-09 | — | — | US | disclosed |