Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G2A | P14555 | 7/20 | 0.37 |
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.37 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.37 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | PLA2G10 | O15496 | 1/20 | 0.35 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.35 |
| ▸ | PLA2G5 | P39877 | 1/20 | 0.35 |
| ▸ | PLA2G2E | Q9NZK7 | 1/20 | 0.35 |
| ▸ | PTGIR | P43119 | 5/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | CASP1 | P29466 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.34 |
| ▸ | GLA | P06280 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14628608 | 0.89 | PTGIR (0.38) | PLA2G2APTGDR2DDB1CRBNPOLB | |
| SCHEMBL14628639 | 0.89 | DDB1 (0.39) | PLA2G2APTGDR2DDB1CRBNPLA2G1B | |
| SCHEMBL14628606 | 0.84 | PLA2G2A (0.38) | PLA2G2APTGDR2DDB1CRBNPOLB | |
| SCHEMBL14628642 | 0.80 | GAA (0.40) | POLBKDM4EALDH1A1TDP1CASP1 | |
| SCHEMBL14628607 | 0.79 | DDB1 (0.38) | PLA2G2ADDB1CRBNPLA2G1BKDM4E | |
| SCHEMBL14628605 | 0.75 | MAPKAPK2 (0.43) | KDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL14598618 | 0.72 | PLA2G2A (0.58) | PLA2G2APLA2G10PLA2G1BPLA2G5PLA2G2E | |
| SCHEMBL14628611 | 0.69 | HTR2C (0.42) | KDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL30007166 | 0.69 | PLA2G2A (0.46) | PLA2G2APTGDR2POLBSMN1; SMN2PLA2G10 | |
| SCHEMBL14628656 | 0.68 | MAPKAPK2 (0.45) | KDM4EALDH1A1HPGDHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7160909-B2 | Cyclopenta[b]indole derivatives as sPLA2 inhibitors | ELI LILLY AND COMPANY (US) | 2007-01-09 | — | — | US | disclosed |