Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DDB1 | Q16531 | 1/20 | 0.39 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.39 |
| ▸ | PLA2G2A | P14555 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.35 |
| ▸ | MAPT | P10636 | 3/20 | 0.35 |
| ▸ | PLA2G1B | P04054 | 2/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.33 |
| ▸ | PTGDR | Q13258 | 1/20 | 0.33 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | ADRB2 | P07550 | 3/20 | 0.33 |
| ▸ | DRD2 | P14416 | 3/20 | 0.33 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.33 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.33 |
| ▸ | TLR4 | O00206 | 2/20 | 0.33 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.33 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14628607 | 0.90 | DDB1 (0.38) | DDB1CRBNPLA2G2AKDM4EALDH1A1 | |
| SCHEMBL14628640 | 0.89 | PLA2G2A (0.37) | DDB1CRBNPLA2G2AKDM4EALDH1A1 | |
| SCHEMBL14628657 | 0.85 | DDB1 (0.39) | DDB1CRBNPLA2G2AKDM4EALDH1A1 | |
| SCHEMBL14628608 | 0.78 | PTGIR (0.38) | DDB1CRBNPLA2G2AKDM4EALDH1A1 | |
| SCHEMBL14628642 | 0.78 | GAA (0.40) | KDM4EALDH1A1MAPTGAAHTR2A | |
| SCHEMBL14628605 | 0.77 | MAPKAPK2 (0.43) | KDM4EALDH1A1MAPTHPGDHSD17B10 | |
| SCHEMBL14628603 | 0.75 | ALDH1A1 (0.41) | KDM4EALDH1A1MAPTHPGDHSD17B10 | |
| SCHEMBL14628606 | 0.73 | PLA2G2A (0.38) | DDB1CRBNPLA2G2AKDM4EALDH1A1 | |
| SCHEMBL14598620 | 0.73 | PLA2G2A (0.60) | PLA2G2APLA2G1B | |
| SCHEMBL14628611 | 0.72 | HTR2C (0.42) | KDM4EALDH1A1MAPTHPGDHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7160909-B2 | Cyclopenta[b]indole derivatives as sPLA2 inhibitors | ELI LILLY AND COMPANY (US) | 2007-01-09 | — | — | US | disclosed |