SCHEMBL14629708

SCHEMBL14629708

CCC(C)(Cl)c1cccc(Oc2ccc(C(c3ccc(OC(C)(CC)c4cccc(Cl)c4C#N)cc3)(C(F)(F)F)C(F)(F)F)cc2)c1C#N

nearest known ligand 0.36

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
HSD11B1 P28845 1/20 0.36
TLR8 Q9NR97 1/20 0.35
MAPT P10636 1/20 0.35
MEN1 O00255 1/20 0.34
CNR1 P21554 1/20 0.34
GPR183 P32249 1/20 0.34
CNR2 P34972 1/20 0.34
KMT2A Q03164 1/20 0.34
AR P10275 3/20 0.34
MCL1 Q07820 2/20 0.31
BCL2L1 Q07817 1/20 0.31
ADRB2 P07550 1/20 0.30
CYP2D6 P10635 1/20 0.30
SLC6A2 P23975 1/20 0.30
SLC6A4 P31645 1/20 0.30
CASR P41180 1/20 0.30
SLC6A3 Q01959 1/20 0.30
KCNH2 Q12809 1/20 0.30
SLC22A12 Q96S37 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL13298968 0.95 MAPT (0.38) HSD11B1TLR8MAPTMEN1CNR1
SCHEMBL13342162 0.94 HSD11B1 (0.37) HSD11B1TLR8MAPTMEN1CNR1
SCHEMBL12872885 0.93 HSD11B1 (0.41) HSD11B1TLR8MAPTMEN1CNR1
SCHEMBL17750837 0.93 HSD11B1 (0.36) HSD11B1TLR8MAPTMEN1CNR1
SCHEMBL14473602 0.89 HSD11B1 (0.35) HSD11B1TLR8MAPTMEN1CNR1
SCHEMBL13274032 0.88 HSD11B1 (0.37) HSD11B1TLR8MAPTMEN1CNR1
SCHEMBL21423191 0.87 MAPT (0.39) HSD11B1TLR8MAPTMEN1CNR1
SCHEMBL17778617 0.87 HSD11B1 (0.37) HSD11B1TLR8MAPTMEN1CNR1
SCHEMBL12969339 0.86 HSD11B1 (0.36) HSD11B1TLR8MAPTMEN1CNR1
SCHEMBL13478418 0.84 HSD11B1 (0.35) HSD11B1TLR8MAPTMEN1CNR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20070015024-A1 Membrane-electrode assembly for solid polymer electrolyte fuel cell HONDA MOTOR CO., LTD. 2007-01-18 US disclosed