Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PAK1 | Q13153 | 5/20 | 0.37 |
| ▸ | PAK4 | O96013 | 1/20 | 0.37 |
| ▸ | IDO1 | P14902 | 1/20 | 0.36 |
| ▸ | PAK3 | O75914 | 3/20 | 0.35 |
| ▸ | PAK2 | Q13177 | 3/20 | 0.35 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.34 |
| ▸ | CA1 | P00915 | 1/20 | 0.34 |
| ▸ | CA2 | P00918 | 1/20 | 0.34 |
| ▸ | ITGB2 | P05107 | 1/20 | 0.34 |
| ▸ | ICAM1 | P05362 | 1/20 | 0.34 |
| ▸ | ITGAL | P20701 | 1/20 | 0.34 |
| ▸ | CA4 | P22748 | 1/20 | 0.34 |
| ▸ | CA6 | P23280 | 1/20 | 0.34 |
| ▸ | AHR | P35869 | 1/20 | 0.34 |
| ▸ | ADK | P55263 | 1/20 | 0.34 |
| ▸ | MAOB | P27338 | 4/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30587475 | 0.72 | ROCK2 (0.44) | PAK4IDO1TRPA1POLBKDM4E | |
| SCHEMBL12855676 | 0.71 | — | — | |
| SCHEMBL14630025 | 0.71 | AXL (0.39) | TRPA1CA1CA2ITGB2ICAM1 | |
| SCHEMBL31252444 | 0.70 | CHRNA7 (0.35) | PAK1PAK4TRPA1CA1CA2 | |
| SCHEMBL7622138 | 0.69 | ALDH1A1 (0.33) | POLBKDM4EMAPTTSHRHSD17B10 | |
| SCHEMBL19212577 | 0.69 | IDO1 (0.42) | IDO1MAOBPOLBPRMT5KCNH2 | |
| SCHEMBL2352863 | 0.68 | SYK (0.33) | POLBMAPTHSD17B10MAPK8MAPK10 | |
| SCHEMBL9377967 | 0.68 | JAK3 (0.40) | JAK2 | |
| SCHEMBL23625710 | 0.67 | APP (0.44) | TRPA1CA1CA2ITGB2ICAM1 | |
| SCHEMBL7016588 | 0.67 | USP2 (0.43) | TRPA1CA1CA2ITGB2ICAM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2548876-A1 | New CRTh2 antagonists | Almirall, S.A. (ES) | 2013-01-23 | — | — | EP | disclosed |