SCHEMBL1463161

SCHEMBL1463161

O=C(c1ccnc(Cl)c1)[NH+]([O-])c1ccc(C(F)(F)F)nc1C1CCN(C/C=C/c2ccc(Cl)cc2)CC1

nearest known ligand 0.44

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
PROKR1 Q8TCW9 2/20 0.35
EBP Q15125 1/20 0.35
SIGMAR1 Q99720 1/20 0.35
MCHR1 Q99705 2/20 0.34
SMN1; SMN2 Q16637 1/20 0.34
DHCR7 Q9UBM7 1/20 0.33
CCR3 P51677 1/20 0.33
LMNA P02545 1/20 0.33
GPR4 P46093 2/20 0.32
PLA2G1B P04054 1/20 0.32
ATG4B Q9Y4P1 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16494664 1.00 PROKR1 (0.35) PROKR1EBPSIGMAR1MCHR1SMN1; SMN2
SCHEMBL1420947 0.84 MCHR1 (0.40) PROKR1EBPSIGMAR1MCHR1SMN1; SMN2
SCHEMBL1420945 0.84 MCHR1 (0.40) PROKR1EBPSIGMAR1MCHR1SMN1; SMN2
SCHEMBL1462207 0.80 MCHR1 (0.39) PROKR1EBPSIGMAR1MCHR1SMN1; SMN2
SCHEMBL1462205 0.80 MCHR1 (0.39) PROKR1EBPSIGMAR1MCHR1SMN1; SMN2
SCHEMBL1420624 0.76 MCHR1 (0.40) PROKR1EBPSIGMAR1MCHR1SMN1; SMN2
SCHEMBL1463147 0.76 MCHR1 (0.40) PROKR1EBPSIGMAR1MCHR1SMN1; SMN2
SCHEMBL1420623 0.76 MCHR1 (0.40) PROKR1EBPSIGMAR1MCHR1SMN1; SMN2
SCHEMBL1463140 0.76 MCHR1 (0.40) PROKR1EBPSIGMAR1MCHR1SMN1; SMN2
2-Ethylhexanoic Acid SCHEMBL1463159 0.75 LMNA (0.37) PROKR1EBPSIGMAR1MCHR1CCR3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8193362-B2 Insecticidal compounds SYNGENTA CROP PROTECTION LLC (US) 2012-06-05 US disclosed
US-20110071191-A1 INSECTICIDAL COMPOUNDS SYNGENTA CROP PROTECTION, INC. (US) 2011-03-24 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110071191-A1 INSECTICIDAL COMPOUNDS CBR3, CBR1, ACHE PROKR1 548/4885EBP 723/4885SIGMAR1 237/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.