Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM1 | Q13255 | 9/20 | 0.51 |
| ▸ | GRM5 | P41594 | 8/20 | 0.51 |
| ▸ | TNK2 | Q07912 | 2/20 | 0.49 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.47 |
| ▸ | CDK9 | P50750 | 3/20 | 0.46 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.46 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.45 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.45 |
| ▸ | ATR | Q13535 | 1/20 | 0.44 |
| ▸ | BTK | Q06187 | 1/20 | 0.43 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22328950 | 0.89 | GRM1 (0.57) | GRM1GRM5TNK2CYP11B2CDK9 | |
| SCHEMBL74150 | 0.87 | TNK2 (0.49) | GRM1GRM5TNK2CYP11B2PDE10A | |
| SCHEMBL21512721 | 0.87 | TNK2 (0.49) | GRM1GRM5TNK2CYP11B2PDE10A | |
| SCHEMBL29968677 | 0.87 | TNK2 (0.49) | GRM1GRM5TNK2CYP11B2PDE10A | |
| SCHEMBL31046588 | 0.87 | GRM1 (0.51) | GRM1GRM5TNK2CYP11B2CDK9 | |
| SCHEMBL29335120 | 0.87 | GRM1 (0.51) | GRM1GRM5TNK2CYP11B2CDK9 | |
| SCHEMBL31652198 | 0.86 | GRM1 (0.50) | GRM1GRM5TNK2CYP11B2CDK9 | |
| SCHEMBL21060469 | 0.85 | GRM1 (0.55) | GRM1GRM5TNK2CYP11B2CDK9 | |
| SCHEMBL30675208 | 0.85 | GRM1 (0.55) | GRM1GRM5TNK2CYP11B2CDK9 | |
| SCHEMBL20835958 | 0.83 | GRM1 (0.48) | GRM1GRM5TNK2CYP11B2CDK9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10034476-B2 | Insecticidal phenyl-or pyridyl-piperdine compounds | SYNGENTA PARTICIPATIONS AG (CH) | 2018-07-31 | — | — | US | disclosed |
| US-20170347650-A1 | INSECTICIDAL PHENYL-OR PYRIDYL-PIPERDINE COMPOUNDS | SYNGENTA PARTICIPATIONS AG (CH) | 2017-12-07 | — | — | US | disclosed |
| US-9808006-B2 | Insecticidal phenyl-or pyridyl-piperdine compounds | SYNGENTA PARTICIPATIONS AG (CH) | 2017-11-07 | — | — | US | disclosed |
| EP-2451801-B1 | INSECTICIDAL COMPOUNDS | SYNGENTA PARTICIPATIONS AG (CH) | 2014-08-13 | — | — | EP | disclosed |
| US-20130317062-A1 | INSECTICIDAL PHENYL-OR PYRIDYL-PIPERDINE COMPOUNDS | SYNGENTA PARTICIPATIONS AG (CH) | 2013-11-28 | — | — | US | disclosed |
| US-8586593-B2 | Insecticidal compounds | SYNGENTA CROP PROTECTION, INC. (US) | 2013-11-19 | — | — | US | disclosed |
| US-8518971-B2 | Insecticidal phenyl- or pyridyl-piperdine compounds | SYNGENTA CROP PROTECTION, INC. (US) | 2013-08-27 | — | — | US | disclosed |
| US-8193362-B2 | Insecticidal compounds | SYNGENTA CROP PROTECTION LLC (US) | 2012-06-05 | — | — | US | disclosed |
| WO-2012037282-A3 | CATALYSTS AND METHODS FOR POLYMER SYNTHESIS | NOVOMER, INC. (US) | 2012-05-10 | — | — | WO | disclosed |
| US-20120115884-A1 | INSECTICIDAL COMPOUNDS | SYNGENTA CROP PROTECTION LLC (US) | 2012-05-10 | — | — | US | disclosed |
| EP-2297136-B1 | INSECTICIDAL PYRIDYLPIPERIDINE COMPOUNDS | SYNGENTA PARTICIPATIONS AG (CH) | 2011-12-28 | — | — | EP | disclosed |
| EP-2324010-B1 | INSECTICIDAL PHENYL- OR PYRIDYL-PIPERIDINE COMPOUNDS | SYNGENTA PARTICIPATIONS AG (CH) | 2011-11-30 | — | — | EP | disclosed |
| US-20110136866-A1 | INSECTICIDAL PHENYL- OR PYRIDYL-PIPERDINE COMPOUNDS | SYNGENTA CROP PROTECTION LLC (US) | 2011-06-09 | — | — | US | disclosed |
| US-20110071191-A1 | INSECTICIDAL COMPOUNDS | SYNGENTA CROP PROTECTION, INC. (US) | 2011-03-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10034476-B2 | Insecticidal phenyl-or pyridyl-piperdine compounds | ACHE, CHRM1, CHRM2 | GRM1 1545/4885GRM5 2188/4885TNK2 2564/4885 |
| US-20120115884-A1 | INSECTICIDAL COMPOUNDS | ACHE, C1R, C5 | GRM1 2677/4885GRM5 3003/4885TNK2 3397/4885 |
| US-20130317062-A1 | INSECTICIDAL PHENYL-OR PYRIDYL-PIPERDINE COMPOUNDS | ACHE, CHRM1, CHRM2 | GRM1 1545/4885GRM5 2188/4885TNK2 2564/4885 |
| US-20110071191-A1 | INSECTICIDAL COMPOUNDS | CBR3, CBR1, ACHE | GRM1 3635/4885GRM5 3391/4885TNK2 2560/4885 |
| US-20110136866-A1 | INSECTICIDAL PHENYL- OR PYRIDYL-PIPERDINE COMPOUNDS | ACHE, CHRM1, CHRM2 | GRM1 1446/4885GRM5 1935/4885TNK2 2366/4885 |
| US-20170347650-A1 | INSECTICIDAL PHENYL-OR PYRIDYL-PIPERDINE COMPOUNDS | ACHE, CHRM1, CHRM2 | GRM1 1545/4885GRM5 2188/4885TNK2 2564/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.