SCHEMBL14634467

SCHEMBL14634467

N#Cc1cnc(OC2CCC(OC3CCN(C(=O)O)CC3)CC2)cn1

nearest known ligand 0.73

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
GPR119 Q8TDV5 19/20 0.73
JAK3 P52333 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14634468 1.00 GPR119 (0.73) GPR119JAK3
SCHEMBL14634164 0.85 GPR119 (1.00) GPR119
SCHEMBL12283097 0.85 GPR119 (1.00) GPR119
SCHEMBL2553243 0.81 GPR119 (0.50) GPR119
SCHEMBL2553246 0.81 GPR119 (0.50) GPR119
SCHEMBL5265331 0.78 GPR119 (0.46) GPR119
SCHEMBL14634273 0.78 GPR119 (0.75) GPR119
SCHEMBL14634274 0.78 GPR119 (0.75) GPR119
SCHEMBL2550744 0.77 GPR119 (0.56) GPR119
SCHEMBL23924451 0.77 GPR119 (0.53) GPR119JAK3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20130023494-A1 MODULATORS OF THE GPR119 RECEPTOR AND THE TREATMENT OF DISORDERS RELATED THERETO ARENA PHARMACEUTICALS, INC. (US) 2013-01-24 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20130023494-A1 MODULATORS OF THE GPR119 RECEPTOR AND THE TREATMENT OF DISORDERS RELATED THERETO GPR119, SLC5A2, SLC5A1 GPR119 1/4885JAK3 3987/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.