Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 3/20 | 0.53 |
| ▸ | CHEK1 | O14757 | 10/20 | 0.39 |
| ▸ | RPS6KA3 | P51812 | 3/20 | 0.37 |
| ▸ | SRPK1 | Q96SB4 | 2/20 | 0.37 |
| ▸ | JAK3 | P52333 | 1/20 | 0.36 |
| ▸ | TRPC3 | Q13507 | 1/20 | 0.36 |
| ▸ | TRPC6 | Q9Y210 | 1/20 | 0.36 |
| ▸ | CHEK2 | O96017 | 2/20 | 0.35 |
| ▸ | BRD4 | O60885 | 2/20 | 0.35 |
| ▸ | DPP4 | P27487 | 1/20 | 0.34 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.34 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.34 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.34 |
| ▸ | FLT4 | P35916 | 2/20 | 0.33 |
| ▸ | KDR | P35968 | 2/20 | 0.33 |
| ▸ | GSK3B | P49841 | 2/20 | 0.33 |
| ▸ | STK3 | Q13188 | 2/20 | 0.33 |
| ▸ | PLK4 | O00444 | 1/20 | 0.33 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.33 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21665749 | 0.86 | GPR119 (0.67) | GPR119MAP4K4 | |
| SCHEMBL30938143 | 0.86 | GPR119 (0.67) | GPR119MAP4K4 | |
| SCHEMBL14634468 | 0.77 | GPR119 (0.73) | GPR119JAK3 | |
| SCHEMBL14634467 | 0.77 | GPR119 (0.73) | GPR119JAK3 | |
| SCHEMBL21807918 | 0.73 | HCRTR1 (0.34) | GPR119 | |
| SCHEMBL21645375 | 0.72 | GPR119 (0.44) | GPR119CHEK1TRPC3TRPC6CHEK2 | |
| SCHEMBL30991254 | 0.72 | GPR119 (0.44) | GPR119CHEK1TRPC3TRPC6CHEK2 | |
| SCHEMBL22323337 | 0.72 | GPR119 (0.33) | GPR119 | |
| Hydrochloric Acid SCHEMBL21645371 | 0.71 | GPR119 (0.43) | GPR119CHEK1TRPC3TRPC6CHEK2 | |
| Hydrochloric Acid SCHEMBL30991239 | 0.71 | GPR119 (0.43) | GPR119CHEK1TRPC3TRPC6CHEK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11999726-B2 | 5-methyl-4-fluoro-thiazol-2-yl compounds | ELI LILLY AND COMPANY | 2024-06-04 | — | — | US | disclosed |
| EP-3829716-B1 | 5-METHYL-4-FLUORO-THIAZOL-2-YL COMPOUNDS | LILLY CO ELI (US) | 2023-02-01 | — | — | EP | disclosed |
| US-20210323958-A1 | 5-METHYL-4-FLUORO-THIAZOL-2-YL COMPOUNDS | ELI LILLY AND COMPANY | 2021-10-21 | — | — | US | disclosed |
| CN-112469476-A | 5-methyl-4-fluoro-thiazol-2-yl compounds | 伊莱利利公司 | 2021-03-09 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210323958-A1 | 5-METHYL-4-FLUORO-THIAZOL-2-YL COMPOUNDS | MAPT, PSEN2, PSEN1 | GPR119 316/4885CHEK1 4760/4885RPS6KA3 2991/4885 |
| US-11999726-B2 | 5-methyl-4-fluoro-thiazol-2-yl compounds | MAPT, PSEN2, PSEN1 | GPR119 316/4885CHEK1 4760/4885RPS6KA3 2991/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.