Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.39 |
| ▸ | RET | P07949 | 1/20 | 0.38 |
| ▸ | HTR2B | P41595 | 4/20 | 0.38 |
| ▸ | HTR2A | P28223 | 3/20 | 0.38 |
| ▸ | HTR2C | P28335 | 3/20 | 0.38 |
| ▸ | PIK3CD | O00329 | 5/20 | 0.37 |
| ▸ | ABL1 | P00519 | 5/20 | 0.37 |
| ▸ | EGFR | P00533 | 5/20 | 0.37 |
| ▸ | HCK | P08631 | 5/20 | 0.37 |
| ▸ | SRC | P12931 | 5/20 | 0.37 |
| ▸ | KDR | P35968 | 5/20 | 0.37 |
| ▸ | PIK3CA | P42336 | 5/20 | 0.37 |
| ▸ | PIK3CB | P42338 | 5/20 | 0.37 |
| ▸ | MTOR | P42345 | 5/20 | 0.37 |
| ▸ | PIK3CG | P48736 | 5/20 | 0.37 |
| ▸ | EPHB4 | P54760 | 5/20 | 0.37 |
| ▸ | PRKDC | P78527 | 5/20 | 0.37 |
| ▸ | PI4KB | Q9UBF8 | 4/20 | 0.37 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.37 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14635974 | 1.00 | RPS6KA5 (0.39) | RPS6KA5RETHTR2BHTR2AHTR2C | |
| Hydrochloric Acid SCHEMBL21903715 | 0.99 | RPS6KA5 (0.38) | RPS6KA5RETHTR2BHTR2AHTR2C | |
| Hydrochloric Acid SCHEMBL21903713 | 0.99 | RPS6KA5 (0.38) | RPS6KA5RETHTR2BHTR2AHTR2C | |
| Hydrochloric Acid SCHEMBL31684272 | 0.99 | RPS6KA5 (0.38) | RPS6KA5RETHTR2BHTR2AHTR2C | |
| SCHEMBL5818451 | 0.85 | RPS6KA5 (0.39) | RPS6KA5RETHTR2BHTR2AHTR2C | |
| Hydrochloric Acid SCHEMBL6273573 | 0.84 | RPS6KA5 (0.38) | RPS6KA5RETHTR2BHTR2AHTR2C | |
| SCHEMBL24429388 | 0.83 | RET (0.42) | RETPIK3CDABL1EGFRHCK | |
| SCHEMBL28371167 | 0.81 | HTR6 (0.37) | RPS6KA5RETHTR2BPIK3CDABL1 | |
| SCHEMBL28371168 | 0.81 | HTR6 (0.37) | RPS6KA5RETHTR2BPIK3CDABL1 | |
| SCHEMBL17779748 | 0.80 | JAK2 (0.54) | RETPIK3CDABL1EGFRHCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2734529-B1 | BTK INHIBITORS | MERCK SHARP & DOHME (US) | 2018-09-05 | — | — | EP | disclosed |
| US-9718828-B2 | BTK Inhibitors | MERCK SHARP & DOHME CORP. (US) | 2017-08-01 | — | — | US | disclosed |
| US-20170008899-A1 | BTK INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2017-01-12 | — | — | US | disclosed |
| US-20140221333-A1 | BTK INHIBITORS | MERCK SHARP & DOHME B.V. (NL) | 2014-08-07 | — | — | US | disclosed |
| EP-2734529-A1 | BTK INHIBITORS | Merck Sharp & Dohme Corp. (US) | 2014-05-28 | — | — | EP | disclosed |
| WO-2013010380-A1 | BTK INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2013-01-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170008899-A1 | BTK INHIBITORS | BTK, SYK, ABL1 | RPS6KA5 199/4885RET 470/4885HTR2B 4289/4885 |
| US-20140221333-A1 | BTK INHIBITORS | BTK, SYK, ABL1 | RPS6KA5 219/4885RET 485/4885HTR2B 4222/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.