Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.39 |
| ▸ | RET | P07949 | 3/20 | 0.38 |
| ▸ | SRC | P12931 | 6/20 | 0.38 |
| ▸ | KDR | P35968 | 5/20 | 0.38 |
| ▸ | JAK2 | O60674 | 2/20 | 0.38 |
| ▸ | CDC7 | O00311 | 1/20 | 0.38 |
| ▸ | PLK4 | O00444 | 1/20 | 0.38 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.38 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.38 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.38 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.38 |
| ▸ | INSR | P06213 | 1/20 | 0.38 |
| ▸ | LCK | P06239 | 1/20 | 0.38 |
| ▸ | FYN | P06241 | 1/20 | 0.38 |
| ▸ | CDK1 | P06493 | 1/20 | 0.38 |
| ▸ | ROS1 | P08922 | 1/20 | 0.38 |
| ▸ | FER | P16591 | 1/20 | 0.38 |
| ▸ | PRKACA | P17612 | 1/20 | 0.38 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.38 |
| ▸ | CDK2 | P24941 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL6273573 | 0.99 | RPS6KA5 (0.38) | RPS6KA5RETSRCKDRJAK2 | |
| SCHEMBL26790960 | 0.93 | SRC (0.43) | RETSRCKDRJAK2CDC7 | |
| SCHEMBL14635975 | 0.85 | RPS6KA5 (0.39) | RPS6KA5RETSRCKDRJAK2 | |
| SCHEMBL14635974 | 0.85 | RPS6KA5 (0.39) | RPS6KA5RETSRCKDRJAK2 | |
| SCHEMBL6665772 | 0.85 | MEN1 (0.46) | RPS6KA5RETSRCKDRJAK2 | |
| Hydrochloric Acid SCHEMBL21903713 | 0.84 | RPS6KA5 (0.38) | RPS6KA5RETSRCKDRJAK2 | |
| Hydrochloric Acid SCHEMBL21903715 | 0.84 | RPS6KA5 (0.38) | RPS6KA5RETSRCKDRJAK2 | |
| Hydrochloric Acid SCHEMBL31684272 | 0.84 | RPS6KA5 (0.38) | RPS6KA5RETSRCKDRJAK2 | |
| SCHEMBL24096562 | 0.83 | RET (0.51) | RETSRCKDRJAK2CDC7 | |
| SCHEMBL28371168 | 0.81 | HTR6 (0.37) | RPS6KA5RETSRCKDREGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1385524-A4 | PYRAZOLOPYRIMIDINES AS THERAPEUTIC AGENTS | ABBOTT GMBH & CO KG (DE) | 2006-02-01 | — | — | EP | disclosed |
| EP-1385524-A1 | PYRAZOLOPYRIMIDINES AS THERAPEUTIC AGENTS | Abbott GmbH & Co. KG (DE) | 2004-02-04 | — | — | EP | disclosed |
| WO-2002080926-A1 | PYRAZOLOPYRIMIDINES AS THERAPEUTIC AGENTS | ABBOTT GMBH & CO. KG (DE) | 2002-10-17 | — | — | WO | disclosed |