Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 4/20 | 0.52 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.44 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.43 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.43 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.42 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1463978 | 0.86 | KCNH2 (0.60) | KCNH2HRH3CYP3A4ALDH1A1KDM4E | |
| SCHEMBL1463663 | 0.86 | KCNH2 (0.59) | KCNH2HRH3CYP3A4KCNA5ALDH1A1 | |
| SCHEMBL1463588 | 0.86 | KCNH2 (0.52) | KCNH2HRH3CYP3A4ALDH1A1KDM4E | |
| SCHEMBL1463802 | 0.81 | G6PD (0.59) | KCNH2HRH3CYP3A4ALDH1A1KDM4E | |
| SCHEMBL1463084 | 0.80 | KCNH2 (0.58) | KCNH2HRH3CYP3A4ALDH1A1CYP1A2 | |
| SCHEMBL1463838 | 0.79 | KCNH2 (0.60) | KCNH2HRH3CYP3A4ALDH1A1KDM4E | |
| SCHEMBL1463880 | 0.79 | KCNH2 (0.60) | KCNH2HRH3CYP3A4ALDH1A1KDM4E | |
| SCHEMBL1462814 | 0.77 | KCNH2 (0.60) | KCNH2HRH3KCNA5ALDH1A1KDM4E | |
| SCHEMBL1463739 | 0.77 | CYP1A2 (0.49) | KCNH2HRH3CYP3A4TP53ALDH1A1 | |
| SCHEMBL1376904 | 0.77 | KCNA5 (0.59) | KCNH2TP53KCNA5ALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110071148-A1 | COMPOUNDS AS THE ESTROGEN RELATED RECEPTORS MODULATORS AND THE USES THEREOF | GUANGZHOU INSTITUTE OF BIOMEDICINE AND HEALTH, CHINESE ACADEMY OF SCIENCES (CN) | 2011-03-24 | — | — | US | claimed |
| US-20110071148-A1 | COMPOUNDS AS THE ESTROGEN RELATED RECEPTORS MODULATORS AND THE USES THEREOF | GUANGZHOU INSTITUTE OF BIOMEDICINE AND HEALTH, CHINESE ACADEMY OF SCIENCES (CN) | 2011-03-24 | — | — | US | disclosed |
| EP-2266962-A1 | THE COMPOUNDS AS THE ESTROGEN RELATED RECEPTORS MODULATORS AND THE USES THEREOF | Guangzhou Institute Of Biomedicine And Health, Chinese Academy Of Sciences (CN) | 2010-12-29 | — | — | EP | disclosed |
| CN-101531638-A | Compounds useful as estrogen-related receptor modulators and uses thereof | CHINESE ACADEMY OF SCIENCES GU | 2009-09-16 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110071148-A1 | COMPOUNDS AS THE ESTROGEN RELATED RECEPTORS MODULATORS AND THE USES THEREOF | ESRRA, ESRRB, ESRRG | KCNH2 4431/4885HRH3 2531/4885CYP3A4 142/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.