Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | MTNR1A | P48039 | 7/20 | 0.34 |
| ▸ | MTNR1B | P49286 | 7/20 | 0.34 |
| ▸ | KISS1R | Q969F8 | 2/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | MMP1 | P03956 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | PAOX | Q6QHF9 | 2/20 | 0.30 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.30 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17275459 | 0.82 | CYP2D6 (0.50) | ALDH1A1CYP2D6CYP2C19 | |
| SCHEMBL5610698 | 0.80 | HIF1A (0.42) | KDM4EMAPK1HIF1ANPC1MTNR1A | |
| SCHEMBL7082573 | 0.76 | OR51E2 (0.42) | KDM4EMAPK1HIF1ANPC1MTNR1A | |
| SCHEMBL19057919 | 0.76 | MMP1 (0.38) | KDM4EMAPK1HIF1ANPC1MTNR1A | |
| SCHEMBL16688760 | 0.76 | KDM4E (0.34) | KDM4EMAPK1HIF1ANPC1MTNR1A | |
| SCHEMBL18361542 | 0.72 | MEN1 (0.44) | KDM4ECYP2D6 | |
| SCHEMBL1866035 | 0.72 | KDM4E (0.43) | KDM4EMAPK1HIF1ANPC1MTNR1A | |
| SCHEMBL7826230 | 0.72 | — | — | |
| SCHEMBL1866034 | 0.72 | KDM4E (0.43) | KDM4EMAPK1HIF1ANPC1MTNR1A | |
| SCHEMBL13411703 | 0.72 | KDM4E (0.43) | KDM4EMAPK1HIF1ANPC1MTNR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070010489-A1 | Cellular accumulation of phosphonate analogs of hiv protease inhibitor compounds | GILEAD SCIENCES, INC. | 2007-01-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070010489-A1 | Cellular accumulation of phosphonate analogs of hiv protease inhibitor compounds | PPA1, PNP, PPME1 | KDM4E 3256/4885MAPK1 2930/4885HIF1A 4003/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.