Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH3 | Q9ULD8 | 1/20 | 0.40 |
| ▸ | CSF1R | P07333 | 2/20 | 0.39 |
| ▸ | CCNT1 | O60563 | 3/20 | 0.38 |
| ▸ | PDE5A | O76074 | 6/20 | 0.37 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | CDK9 | P50750 | 3/20 | 0.35 |
| ▸ | CCNK | O75909 | 1/20 | 0.34 |
| ▸ | FLT3 | P36888 | 1/20 | 0.34 |
| ▸ | CNR2 | P34972 | 1/20 | 0.34 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.34 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.34 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.33 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.33 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12501639 | 0.81 | ALDH1A1 (0.48) | CCNT1ALDH1A1CDK9SCN5A | |
| SCHEMBL12827199 | 0.77 | CCNT1 (0.45) | KCNH3CSF1RCCNT1PDE5AHIF1A | |
| SCHEMBL1192545 | 0.77 | CCNT1 (0.46) | KCNH3CSF1RCCNT1PDE5AHIF1A | |
| SCHEMBL1192610 | 0.74 | CCNT1 (0.45) | KCNH3CSF1RCCNT1PDE5AHIF1A | |
| SCHEMBL1225598 | 0.72 | CCNT1 (0.35) | CCNT1CDK9 | |
| SCHEMBL1191926 | 0.71 | PDE5A (0.43) | KCNH3CSF1RCCNT1PDE5AHIF1A | |
| SCHEMBL14828502 | 0.69 | CCNT1 (0.33) | CCNT1CDK9CCNK | |
| SCHEMBL23899720 | 0.67 | CNR2 (0.47) | KCNH3CCNT1PDE5AALDH1A1CDK9 | |
| SCHEMBL20448552 | 0.67 | KCNH3 (0.47) | KCNH3CSF1RCCNT1HIF1AALDH1A1 | |
| SCHEMBL12542004 | 0.67 | PTGS1 (0.41) | KCNH3CSF1RCCNT1PDE5AHIF1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012101064-A1 | N-ACYL PYRIMIDINE BIARYL COMPOUNDS AS PROTEIN KINASE INHIBITORS | NOVARTIS AG (CH) | 2012-08-02 | — | — | WO | disclosed |
| WO-2012101063-A1 | N-ACYL PYRIDINE BIARYL COMPOUNDS AND THEIR USES | NOVARTIS AG (CH) | 2012-08-02 | — | — | WO | disclosed |
| EP-2473499-A1 | BIPYRIDINES USEFUL FOR THE TREATMENT OF PROLIFERATIVE DISEASES | Novartis AG (CH) | 2012-07-11 | — | — | EP | disclosed |
| WO-2011026911-A1 | BIPYRIDINES USEFUL FOR THE TREATMENT OF PROLIFERATIVE DISEASES | NOVARTIS AG (CH) | 2011-03-10 | — | — | WO | disclosed |