Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 1/20 | 0.54 |
| ▸ | ATAD2 | Q6PL18 | 1/20 | 0.54 |
| ▸ | TSHR | P16473 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 4/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | OGG1 | O15527 | 1/20 | 0.39 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.39 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.39 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.39 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27749835 | 0.93 | LMNA (0.45) | BRD4ATAD2TSHRLMNACYP1A2 | |
| SCHEMBL27749593 | 0.83 | MEN1 (0.45) | ATAD2TSHRLMNACYP1A2CYP3A4 | |
| SCHEMBL8809305 | 0.79 | KDM4E (0.58) | BRD4ATAD2TSHRLMNAMAPT | |
| SCHEMBL29984623 | 0.78 | BRD4 (0.59) | BRD4ATAD2TSHRKDM4EHSD17B10 | |
| SCHEMBL398708 | 0.78 | BRD4 (0.59) | BRD4ATAD2TSHRKDM4EHSD17B10 | |
| SCHEMBL12563933 | 0.77 | NR1H2 (0.52) | TSHRLMNACYP1A2CYP3A4CYP2C9 | |
| SCHEMBL3585586 | 0.76 | BRD4 (0.68) | BRD4ATAD2LMNAOGG1PDK1 | |
| SCHEMBL30575701 | 0.76 | BRD4 (0.68) | BRD4ATAD2LMNAOGG1PDK1 | |
| SCHEMBL396271 | 0.75 | BRD4 (0.69) | BRD4ATAD2TSHRMAPTALDH1A1 | |
| SCHEMBL3653540 | 0.75 | NR1H2 (0.56) | TSHRLMNACYP1A2CYP3A4CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2731953-A1 | TRICYCLIC INHIBITORS OF KINASES USEFUL FOR THE TREATMENT OF PROLIFERATIVE DISEASES | Abbvie Inc. (US) | 2014-05-21 | — | — | EP | disclosed |
| WO-2013012681-A1 | TRICYCLIC INHIBITORS OF KINASES USEFUL FOR THE TREATMENT OF PROLIFERATIVE DISEASES | ABBOTT LABORATORIES (US) | 2013-01-24 | — | — | WO | disclosed |