Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.58 |
| ▸ | PDK1 | Q15118 | 2/20 | 0.54 |
| ▸ | PDK2 | Q15119 | 2/20 | 0.54 |
| ▸ | PDK3 | Q15120 | 2/20 | 0.54 |
| ▸ | PDK4 | Q16654 | 2/20 | 0.54 |
| ▸ | ATAD2 | Q6PL18 | 2/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.50 |
| ▸ | BRD4 | O60885 | 1/20 | 0.50 |
| ▸ | AVPR2 | P30518 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6846584 | 0.83 | NR1H2 (0.56) | KDM4EPDK1PDK2PDK3PDK4 | |
| SCHEMBL7416330 | 0.81 | NOTUM (0.62) | KDM4EPDK1PDK2PDK3PDK4 | |
| SCHEMBL25804434 | 0.81 | CHRM2 (0.50) | KDM4EPDK1PDK2PDK3PDK4 | |
| SCHEMBL30767099 | 0.81 | NOTUM (0.59) | KDM4EHSD17B10SMN1; SMN2ALDH1A1NPSR1 | |
| SCHEMBL27749593 | 0.81 | MEN1 (0.45) | PDK1PDK2PDK3PDK4ATAD2 | |
| SCHEMBL5696394 | 0.81 | NOTUM (0.59) | KDM4EHSD17B10SMN1; SMN2ALDH1A1NPSR1 | |
| SCHEMBL7830713 | 0.80 | KDM4E (0.52) | KDM4EPDK1PDK2PDK3PDK4 | |
| SCHEMBL5426108 | 0.80 | NOTUM (0.65) | SMN1; SMN2ALDH1A1HPGDMEN1KMT2A | |
| SCHEMBL20899580 | 0.80 | PDK1 (0.61) | KDM4EPDK1PDK2PDK3PDK4 | |
| SCHEMBL2289614 | 0.80 | SMN1; SMN2 (0.57) | KDM4ESMN1; SMN2ALDH1A1NPSR1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0757687-A1 | TRICYCLIC DERIVATIVES AS 5HT 2C? AND 5HT 2B? ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1997-02-12 | — | — | EP | disclosed |
| WO-1995029177-A1 | TRICYCLIC DERIVATIVES AS 5HT2C AND 5HT2B ANTAGONISTS | SMITHKLINE BEECHAM P.L.C. (GB) | 1995-11-02 | — | — | WO | disclosed |