Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP1 | P03956 | 20/20 | 0.83 |
| ▸ | ADAM17 | P78536 | 9/20 | 0.83 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.69 |
| ▸ | TNF | P01375 | 1/20 | 0.69 |
| ▸ | MMP2 | P08253 | 1/20 | 0.69 |
| ▸ | MMP3 | P08254 | 1/20 | 0.69 |
| ▸ | MMP9 | P14780 | 1/20 | 0.69 |
| ▸ | MMP8 | P22894 | 1/20 | 0.69 |
| ▸ | MMP13 | P45452 | 1/20 | 0.69 |
| ▸ | MMP14 | P50281 | 1/20 | 0.69 |
| ▸ | ADAMTS1 | Q9UHI8 | 1/20 | 0.69 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.69 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1817324 | 1.00 | MMP1 (0.83) | MMP1ADAM17ADAMTS4TNFMMP2 | |
| Hydroxyamine SCHEMBL28747887 | 0.98 | MMP1 (0.80) | MMP1ADAM17ADAMTS4TNFMMP2 | |
| Hydroxyamine SCHEMBL3518697 | 0.98 | MMP1 (0.80) | MMP1ADAM17ADAMTS4TNFMMP2 | |
| SCHEMBL28747886 | 0.91 | MMP1 (0.79) | MMP1ADAM17ADAMTS4TNFMMP2 | |
| SCHEMBL3518695 | 0.91 | MMP1 (0.79) | MMP1ADAM17ADAMTS4TNFMMP2 | |
| SCHEMBL138144 | 0.91 | MMP1 (1.00) | MMP1ADAM17ADAMTS4TNFMMP2 | |
| SCHEMBL25833 | 0.91 | MMP1 (1.00) | MMP1ADAM17ADAMTS4TNFMMP2 | |
| SCHEMBL138143 | 0.91 | MMP1 (1.00) | MMP1ADAM17ADAMTS4TNFMMP2 | |
| SCHEMBL17479343 | 0.90 | MMP1 (0.83) | MMP1ADAM17ADAMTS4TNFMMP2 | |
| SCHEMBL3518692 | 0.90 | MMP1 (0.70) | MMP1ADAM17ADAMTS4TNFMMP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2734205-A1 | HETEROCYCLIC PROTEIN KINASE INHIBITORS | Tolero Pharmaceuticals, Inc. (US) | 2014-05-28 | — | — | EP | disclosed |
| WO-2013013188-A1 | HETEROCYCLIC PROTEIN KINASE INHIBITORS | TOLERO PHARMACEUTICALS, INC. (US) | 2013-01-24 | — | — | WO | disclosed |