Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP1 | P03956 | 20/20 | 0.83 |
| ▸ | ADAM17 | P78536 | 9/20 | 0.83 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.69 |
| ▸ | TNF | P01375 | 1/20 | 0.69 |
| ▸ | MMP2 | P08253 | 1/20 | 0.69 |
| ▸ | MMP3 | P08254 | 1/20 | 0.69 |
| ▸ | MMP9 | P14780 | 1/20 | 0.69 |
| ▸ | MMP8 | P22894 | 1/20 | 0.69 |
| ▸ | MMP13 | P45452 | 1/20 | 0.69 |
| ▸ | MMP14 | P50281 | 1/20 | 0.69 |
| ▸ | ADAMTS1 | Q9UHI8 | 1/20 | 0.69 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.69 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14639265 | 1.00 | MMP1 (0.83) | MMP1ADAM17ADAMTS4TNFMMP2 | |
| Hydroxyamine SCHEMBL28747887 | 0.98 | MMP1 (0.80) | MMP1ADAM17ADAMTS4TNFMMP2 | |
| Hydroxyamine SCHEMBL3518697 | 0.98 | MMP1 (0.80) | MMP1ADAM17ADAMTS4TNFMMP2 | |
| SCHEMBL28747886 | 0.91 | MMP1 (0.79) | MMP1ADAM17ADAMTS4TNFMMP2 | |
| SCHEMBL3518695 | 0.91 | MMP1 (0.79) | MMP1ADAM17ADAMTS4TNFMMP2 | |
| SCHEMBL138144 | 0.91 | MMP1 (1.00) | MMP1ADAM17ADAMTS4TNFMMP2 | |
| SCHEMBL25833 | 0.91 | MMP1 (1.00) | MMP1ADAM17ADAMTS4TNFMMP2 | |
| SCHEMBL138143 | 0.91 | MMP1 (1.00) | MMP1ADAM17ADAMTS4TNFMMP2 | |
| SCHEMBL17479343 | 0.90 | MMP1 (0.83) | MMP1ADAM17ADAMTS4TNFMMP2 | |
| SCHEMBL3518692 | 0.90 | MMP1 (0.70) | MMP1ADAM17ADAMTS4TNFMMP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2796468-A2 | Antibodies to insulin-like growth factor I receptor | Pfizer Inc (US) | 2014-10-29 | — | — | EP | disclosed |
| EP-1773836-B1 | PYRROLOPYRIMIDINE DERIVATIVES USEFUL IN CANCER TREATMENT | PFIZER PROD INC (US) | 2012-09-05 | — | — | EP | disclosed |
| EP-2322551-A2 | Compositions comprising Anti-IGF-1R Antibodies and Methods for their Production | Amgen, Inc (US) | 2011-05-18 | — | — | EP | disclosed |
| CN-101115760-B | Pyrrolopyrazoles, potent kinase inhibitors | PFIZER | 2010-11-03 | — | — | CN | disclosed |
| CN-101657431-A | Pyrimidine-2, 4-diamine derivatives and their use as JAK2 kinase inhibitors | SUPERGEN INC US | 2010-02-24 | — | — | CN | disclosed |
| CN-101348467-A | Substituted bicyclic derivatives for the treatment of abnormal cell growth | PFIZER (US) | 2009-01-21 | — | — | CN | disclosed |
| CN-101238118-A | Salts and polymorphs of a VEGF-R inhibitor | PFIZER (US) | 2008-08-06 | — | — | CN | disclosed |
| CN-101189239-A | Protein kinase inhibitors | SUPERGEN INC (US) | 2008-05-28 | — | — | CN | disclosed |
| EP-1888588-A2 | PROTEIN KINASE INHIBITORS | SuperGen, Inc. (US) | 2008-02-20 | — | — | EP | disclosed |
| CN-101115760-A | Pyrrolopyrazoles, potent kinase inhibitors | PFIZER (US) | 2008-01-30 | — | — | CN | disclosed |
| CN-1330640-C | Substituted bicyclic derivatives for the treatment of abnormal cell growth | PFIZER PROD INC (US) | 2007-08-08 | — | — | CN | disclosed |
| WO-2006116733-A2 | PROTEIN KINASE INHIBITORS | SUPERGEN, INC. (US) | 2006-11-02 | — | — | WO | disclosed |
| CN-1726218-A | Pyrrolopyrimidine derivatives | PFIZER PROD INC (US) | 2006-01-25 | — | — | CN | disclosed |
| CN-1576275-A | Substituted bicyclic derivatives for the treatment of abnormal cell growth | PFIZER PROD INC (US) | 2005-02-09 | — | — | CN | disclosed |
| CN-1518543-A | Pyrazole derivatives and their use as protein kinase inhibitors | �Ʒ� | 2004-08-04 | — | — | CN | disclosed |
| CN-1444567-A | Imidazole derivatives | PFIZER PROD INC (US) | 2003-09-24 | — | — | CN | disclosed |
| CN-1437594-A | Substituted bicyclic derivatives for the treatment of abnormal cell growth | PFIZER PROD INC (US) | 2003-08-20 | — | — | CN | disclosed |