Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNK3 | O14649 | 1/20 | 0.40 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.40 |
| ▸ | AXL | P30530 | 1/20 | 0.40 |
| ▸ | MAPK14 | Q16539 | 4/20 | 0.38 |
| ▸ | MMP1 | P03956 | 1/20 | 0.38 |
| ▸ | MMP9 | P14780 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | TNIK | Q9UKE5 | 3/20 | 0.35 |
| ▸ | PARP1 | P09874 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | CASP3 | P42574 | 1/20 | 0.35 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.35 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.35 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.35 |
| ▸ | GHSR | Q92847 | 1/20 | 0.34 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12245704 | 0.90 | KCNK3 (0.39) | KCNK3KCNK9AXLMAPK14MMP1 | |
| SCHEMBL2381166 | 0.89 | TERT (0.39) | KCNK3KCNK9AXLMAPK14MMP1 | |
| SCHEMBL2379747 | 0.76 | HDAC2 (0.44) | AXLKMT2AHPGDNPC1RAB9A | |
| SCHEMBL2381797 | 0.74 | KMT2A (0.41) | AXLKMT2AHPGDNPC1RAB9A | |
| SCHEMBL2380299 | 0.73 | ABL1 (0.52) | KCNK3KCNK9NPC1RAB9AAURKA | |
| SCHEMBL2383216 | 0.72 | ABL1 (0.48) | KCNK3KCNK9MAPK14HPGDNPC1 | |
| SCHEMBL2381767 | 0.71 | KCNK3 (0.47) | KCNK3KCNK9MAPK14KMT2AHPGD | |
| SCHEMBL2380902 | 0.70 | KDR (0.50) | KCNK3KCNK9AXLMAPK14AURKA | |
| SCHEMBL14605011 | 0.67 | RAD52 (0.37) | KMT2APOLBHDAC3HDAC1HDAC6 | |
| SCHEMBL5007182 | 0.67 | LMNA (0.46) | MAPK14KMT2AHPGDNPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007005668-A2 | BIS-ARYL KINASE INHIBITORS AND THEIR USE IN THE TREATMENT OF INFLAMMATION, ANGIOGENESIS AND CANCER | AMGEN INC. (US) | 2007-01-11 | — | — | WO | disclosed |