Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | KAT2B | Q92831 | 8/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5917409 | 1.00 | LMNA (0.50) | LMNAKAT2BSMN1; SMN2PKMHPGD | |
| SCHEMBL5917410 | 1.00 | LMNA (0.50) | LMNAKAT2BSMN1; SMN2PKMHPGD | |
| SCHEMBL5593840 | 0.79 | KAT2B (0.49) | LMNAKAT2BSMN1; SMN2HPGDMEN1 | |
| SCHEMBL5593916 | 0.78 | KAT2B (0.47) | KAT2BHPGDMAPTMEN1KMT2A | |
| SCHEMBL14640439 | 0.74 | KAT2B (0.46) | KAT2BPKMHPGDMAPTMEN1 | |
| SCHEMBL8740128 | 0.69 | KMT2A (0.70) | LMNASMN1; SMN2PKMHPGDMAPT | |
| SCHEMBL8740131 | 0.69 | KMT2A (0.70) | LMNASMN1; SMN2PKMHPGDMAPT | |
| SCHEMBL8682896 | 0.69 | LMNA (0.60) | LMNASMN1; SMN2PKMHPGDMAPT | |
| SCHEMBL23241905 | 0.65 | MAPT (0.61) | LMNASMN1; SMN2PKMHPGDMAPT | |
| SCHEMBL15354265 | 0.65 | MAPT (0.61) | LMNASMN1; SMN2PKMHPGDMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007001932-A2 | SUBSTITUTED ISOTHIAZOLONES AS INHIBITORS OF CYTOSOLIC PHOSPHOLIPASE A2 | JANSSEN PHARMACEUTICA N.V. (BE) | 2007-01-04 | — | — | WO | disclosed |