Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 1/20 | 0.41 |
| ▸ | REN | P00797 | 3/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | AR | P10275 | 1/20 | 0.34 |
| ▸ | HTR1A | P08908 | 3/20 | 0.34 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | NOS3 | P29474 | 5/20 | 0.32 |
| ▸ | NOS1 | P29475 | 5/20 | 0.32 |
| ▸ | NOS2 | P35228 | 5/20 | 0.32 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.32 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.32 |
| ▸ | DRD2 | P14416 | 1/20 | 0.32 |
| ▸ | DRD1 | P21728 | 1/20 | 0.32 |
| ▸ | DRD4 | P21917 | 1/20 | 0.32 |
| ▸ | DRD5 | P21918 | 1/20 | 0.32 |
| ▸ | DRD3 | P35462 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12107528 | 0.88 | GRM5 (0.39) | GRM5RENTSHRARHTR1A | |
| SCHEMBL1293871 | 0.81 | REN (0.45) | GRM5RENTSHRARHTR1A | |
| SCHEMBL18055305 | 0.79 | REN (0.42) | GRM5RENTSHRARHTR1A | |
| SCHEMBL12110131 | 0.79 | ESR2 (0.42) | TSHRPRMT5WDR77 | |
| SCHEMBL17525499 | 0.77 | REN (0.43) | GRM5RENTSHRARHTR1A | |
| SCHEMBL12107655 | 0.76 | HTR2C (0.44) | — | |
| SCHEMBL10272585 | 0.76 | REN (0.47) | GRM5RENTSHRHTR1ASLC6A4 | |
| SCHEMBL30659636 | 0.76 | GRM5 (0.40) | GRM5RENTSHRARHTR1A | |
| SCHEMBL12107594 | 0.76 | HRH3 (0.38) | RENARHTR1ASLC6A4 | |
| SCHEMBL38660070 | 0.75 | GRM5 (0.46) | GRM5RENTSHRHTR1ASLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2546255-A1 | BENZAZEPINE COMPOUND | Astellas Pharma Inc. (JP) | 2013-01-16 | — | — | EP | disclosed |