Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 7/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | HTR1A | P08908 | 3/20 | 0.32 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.32 |
| ▸ | NPY5R | Q15761 | 2/20 | 0.31 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | GRM5 | P41594 | 1/20 | 0.31 |
| ▸ | AR | P10275 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14641708 | 0.79 | GRM5 (0.41) | RENCYP3A4HTR1ASLC6A4KCNH2 | |
| SCHEMBL1293871 | 0.79 | REN (0.45) | RENCYP3A4HTR1ASLC6A4HRH3 | |
| SCHEMBL12333093 | 0.72 | REN (0.48) | RENCYP3A4HTR1ASLC6A4KCNH2 | |
| SCHEMBL12107528 | 0.72 | GRM5 (0.39) | RENHTR1ASLC6A4KCNH2HRH3 | |
| SCHEMBL12110156 | 0.71 | GPR119 (0.42) | RENTSHR | |
| SCHEMBL12107698 | 0.71 | HTR2C (0.43) | REN | |
| SCHEMBL12110302 | 0.70 | REN (0.40) | RENHTR1ASLC6A4GRM5TSHR | |
| SCHEMBL17525501 | 0.69 | REN (0.51) | RENCYP3A4HTR1ASLC6A4KCNH2 | |
| SCHEMBL91287 | 0.69 | REN (0.55) | RENHTR1ASLC6A4KCNH2KMT2A | |
| SCHEMBL1083640 | 0.68 | REN (0.54) | RENHTR1ASLC6A4KCNH2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2546255-B1 | BENZAZEPINE COMPOUND | ASTELLAS PHARMA INC (JP) | 2016-08-31 | — | — | EP | disclosed |