Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 13/20 | 0.68 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.48 |
| ▸ | ATM | Q13315 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | CASP1 | P29466 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.46 |
| ▸ | CTSB | P07858 | 1/20 | 0.43 |
| ▸ | ELANE | P08246 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14563111 | 0.89 | CTSK (0.78) | CTSKCTSB | |
| SCHEMBL8091663 | 0.82 | CTSK (1.00) | CTSKCTSB | |
| SCHEMBL2248479 | 0.82 | CTSK (1.00) | CTSKCTSB | |
| SCHEMBL14563097 | 0.79 | CTSK (0.79) | CTSKCTSB | |
| SCHEMBL14563157 | 0.79 | CTSK (0.79) | CTSKCTSB | |
| SCHEMBL14563166 | 0.79 | CTSK (0.67) | CTSKCTSB | |
| SCHEMBL14562945 | 0.78 | CTSK (0.66) | CTSKCTSB | |
| SCHEMBL14563071 | 0.78 | CTSK (0.78) | CTSKCTSB | |
| SCHEMBL1843650 | 0.77 | CTSK (0.51) | CTSKATMMAPTMAPK1 | |
| SCHEMBL14563096 | 0.77 | CTSK (0.65) | CTSKCTSB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2170879-B1 | 1-CYANOCYCLOPROPYL-DERIVATIVES AS CATHEPSIN K INHIBITORS | ASTRAZENECA AB (SE) | 2013-01-16 | — | — | EP | disclosed |