SCHEMBL14642136

SCHEMBL14642136

NCOc1cc(-c2nc(N)nc(Sc3nc4ccccc4s3)n2)c(Cl)cc1Cl

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 4/20 0.40
CYP2D6 P10635 3/20 0.40
CYP2C19 P33261 3/20 0.40
CYP3A4 P08684 2/20 0.40
CYP2C9 P11712 2/20 0.40
STAT6 P42226 1/20 0.40
PTGS1 P23219 1/20 0.36
PTGS2 P35354 1/20 0.36
HSP90AA1 P07900 1/20 0.36
SMN1; SMN2 Q16637 2/20 0.35
MAPK1 P28482 1/20 0.35
HIF1A Q16665 1/20 0.35
L3MBTL1 Q9Y468 1/20 0.35
TP53 P04637 1/20 0.35
MAPT P10636 1/20 0.35
MAOA P21397 1/20 0.35
ALDH1A1 P00352 3/20 0.34
FBP1 P09467 2/20 0.34
HPGD P15428 2/20 0.34
HSD17B10 Q99714 2/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4097995 0.89 HSP90AB1 (0.40) CYP1A2CYP2D6CYP2C19CYP3A4CYP2C9
SCHEMBL13928104 0.79 HSP90AA1 (0.38) HSP90AA1SMN1; SMN2L3MBTL1TP53MAPT
SCHEMBL14642070 0.79 MAPT (0.38) HSP90AA1SMN1; SMN2L3MBTL1TP53MAPT
SCHEMBL14642069 0.76 HSP90AA1 (0.46) CYP1A2CYP2C19CYP3A4CYP2C9HSP90AA1
SCHEMBL4086685 0.71 HSP90AB1 (0.41) HSP90AA1ADORA3POLB
SCHEMBL13927749 0.70 HSP90AA1 (0.34) HSP90AA1
SCHEMBL4086591 0.69 HSP90AB1 (0.45) CYP2C19HSP90AA1L3MBTL1POLB
SCHEMBL4092776 0.69 HSP90AB1 (0.36) HSP90AA1SMN1; SMN2L3MBTL1TP53MAPT
SCHEMBL14642295 0.69 TAS1R3 (0.37) CYP2C19HSP90AA1MAPK1
SCHEMBL4092055 0.68 HSP90AA1 (0.46) HSP90AA1SMN1; SMN2L3MBTL1ADORA3ALOX15

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2036895-B1 HSP90 INHIBITOR CHUGAI PHARMACEUTICAL CO LTD (JP) 2013-01-16 EP disclosed