Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.78 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.78 |
| ▸ | HTT | P42858 | 1/20 | 0.78 |
| ▸ | RAB9A | P51151 | 3/20 | 0.60 |
| ▸ | HPSE | Q9Y251 | 1/20 | 0.57 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.56 |
| ▸ | MAPT | P10636 | 2/20 | 0.55 |
| ▸ | LDLR | P01130 | 1/20 | 0.55 |
| ▸ | NPC1 | O15118 | 2/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.54 |
| ▸ | MMP2 | P08253 | 2/20 | 0.54 |
| ▸ | MMP9 | P14780 | 2/20 | 0.54 |
| ▸ | MMP8 | P22894 | 2/20 | 0.54 |
| ▸ | MMP13 | P45452 | 2/20 | 0.54 |
| ▸ | COMT | P21964 | 1/20 | 0.53 |
| ▸ | STK33 | Q9BYT3 | 1/20 | 0.53 |
| ▸ | TP53 | P04637 | 1/20 | 0.52 |
| ▸ | GFER | P55789 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14642412 | 0.88 | MEN1 (1.00) | MEN1KMT2AHTTRAB9AADORA2A | |
| SCHEMBL13679573 | 0.83 | ADORA2A (0.57) | MEN1KMT2AHTTRAB9AHPSE | |
| SCHEMBL13679607 | 0.82 | MEN1 (0.70) | MEN1KMT2AHTTRAB9AMAPT | |
| SCHEMBL12351223 | 0.82 | COMT (0.79) | MEN1KMT2AHTTRAB9AMAPT | |
| SCHEMBL13679715 | 0.82 | MAPT (0.69) | MEN1KMT2ARAB9AADORA2AMAPT | |
| SCHEMBL14642491 | 0.81 | MEN1 (0.77) | MEN1KMT2AHTTRAB9AMAPT | |
| SCHEMBL13679540 | 0.81 | RAF1 (0.59) | MEN1KMT2AHTTRAB9AHPSE | |
| SCHEMBL13679714 | 0.80 | MEN1 (0.85) | MEN1KMT2AHTTRAB9AMAPT | |
| SCHEMBL13679583 | 0.79 | MAPT (0.80) | MEN1KMT2AHTTRAB9AADORA2A | |
| SCHEMBL14615300 | 0.79 | MAPT (0.71) | MEN1KMT2AHTTRAB9AADORA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8772275-B2 | Mediators of hedgehog signaling pathways, compositions and uses related thereto | CURIS, INC. (US) | 2014-07-08 | — | — | US | disclosed |
| US-8354397-B2 | Controlling cell differentiation, cell proliferation; anticancer agents | CURIS, INC. (US) | 2013-01-15 | — | — | US | disclosed |
| EP-1482928-B1 | MEDIATORS OF HEDGEHOG SIGNALING PATHWAYS,COMPOSITIONS AND USES RELATED THERETO | CURIS INC (US) | 2009-09-23 | — | — | EP | disclosed |