Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.67 |
| ▸ | GAA | P10253 | 4/20 | 0.54 |
| ▸ | MGAM | O43451 | 3/20 | 0.54 |
| ▸ | SI | P14410 | 3/20 | 0.54 |
| ▸ | MGAM2 | Q2M2H8 | 3/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | CASP3 | P42574 | 1/20 | 0.48 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.48 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.48 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13679599 | 0.91 | MGAM (0.57) | MAPTGAAMGAMSIMGAM2 | |
| SCHEMBL1268279 | 0.85 | MAPT (0.85) | MAPTMEN1HTTKMT2ALMNA | |
| SCHEMBL14642404 | 0.85 | MAPT (0.64) | MAPTMEN1HTTKMT2ACASP3 | |
| SCHEMBL14642415 | 0.84 | MAPT (0.65) | MAPTGAAMEN1HTTKMT2A | |
| SCHEMBL14615282 | 0.82 | MAPT (0.68) | MAPTGAAMEN1HTTKMT2A | |
| SCHEMBL13679575 | 0.82 | MAPT (0.73) | MAPTGAAMEN1HTTKMT2A | |
| SCHEMBL13679552 | 0.81 | MAPT (0.69) | MAPTMEN1HTTKMT2A | |
| SCHEMBL13679555 | 0.80 | MEN1 (0.67) | MAPTMEN1HTTKMT2ACASP3 | |
| SCHEMBL13679580 | 0.79 | MAPT (0.67) | MAPTMEN1HTTKMT2A | |
| SCHEMBL4894927 | 0.79 | MAPT (0.52) | MAPTMEN1KMT2ACASP3SENP8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8772275-B2 | Mediators of hedgehog signaling pathways, compositions and uses related thereto | CURIS, INC. (US) | 2014-07-08 | — | — | US | disclosed |
| US-8772275-B2 | Mediators of hedgehog signaling pathways, compositions and uses related thereto | CURIS, INC. (US) | 2014-07-08 | — | — | US | disclosed |
| US-8354397-B2 | Controlling cell differentiation, cell proliferation; anticancer agents | CURIS, INC. (US) | 2013-01-15 | — | — | US | disclosed |
| US-8354397-B2 | Controlling cell differentiation, cell proliferation; anticancer agents | CURIS, INC. (US) | 2013-01-15 | — | — | US | disclosed |
| EP-1482928-B1 | MEDIATORS OF HEDGEHOG SIGNALING PATHWAYS,COMPOSITIONS AND USES RELATED THERETO | CURIS INC (US) | 2009-09-23 | — | — | EP | disclosed |