SCHEMBL146427

SCHEMBL146427

Nc1nc2c(c(=O)[nH]1)NCN2COCCO

nearest known ligand 0.61

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
HPRT1 P00492 10/20 0.61
PNP P00491 10/20 0.50
USP2 O75604 1/20 0.48
TSHR P16473 1/20 0.48
EDNRA P25101 1/20 0.48
HTR2A P28223 1/20 0.48
RECQL P46063 1/20 0.48
BLM P54132 1/20 0.48
HBB P68871 1/20 0.48
HSD17B10 Q99714 1/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11730994 0.97 HPRT1 (0.60) HPRT1PNPUSP2TSHREDNRA
Phosphoric Acid SCHEMBL6439956 0.95 HPRT1 (0.65) HPRT1PNPUSP2TSHREDNRA
Phosphoric Acid SCHEMBL11308939 0.95 HPRT1 (0.65) HPRT1PNPUSP2TSHREDNRA
Phosphoric Acid SCHEMBL11313332 0.94 HPRT1 (0.64) HPRT1PNPUSP2TSHREDNRA
Phosphoric Acid SCHEMBL11327667 0.94 HPRT1 (0.64) HPRT1PNPUSP2TSHREDNRA
Phosphoric Acid SCHEMBL11310331 0.94 HPRT1 (0.64) HPRT1PNPUSP2TSHREDNRA
SCHEMBL8842510 0.93 HPRT1 (0.58) HPRT1PNPUSP2TSHREDNRA
SCHEMBL9057761 0.91 HPRT1 (0.59) HPRT1PNPUSP2TSHREDNRA
Water SCHEMBL11469150 0.90 HPRT1 (0.56) HPRT1PNPUSP2TSHREDNRA
SCHEMBL8149575 0.90 HPRT1 (0.60) HPRT1PNPUSP2TSHREDNRA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1268 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-116804661-A Method for measuring formaldehyde content in antiviral drug of lovir raw material drug by HPLC 湖北省宏源药业科技股份有限公司 2023-09-26 CN claimed
EP-2851368-B1 COMPLEX COMPOUNDS OF GERMANIUM, METHODS FOR PRODUCING SAME, AND DRUGS OBSCHESTVO S OGRANICHENNOI OTVETSTVENNOSTYU WDS FARMA (RU) 2019-01-02 EP claimed
US-9745337-B2 Complex compounds of germanium, methods for producing same, and drugs OBSCHESNO S OGRANICHENNOI OTVETSTVENNOSTYU “WDS FARMA” (RU) 2017-08-29 US claimed
US-20170112792-A1 ENHANCED ATRA-RELATED COMPOUNDS DERIVED FROM STRUCTURE-ACTIVITY RELATIONSHIPS AND MODELING FOR INHIBITING PIN1 BETH ISRAEL DEACONESS MEDICAL CENTER, INC. 2017-04-27 US claimed
WO-2015143190-A1 ENHANCED ATRA-RELATED COMPOUNDS DERIVED FROM STRUCTURE-ACTIVITY RELATIONSHIPS AND MODELING FOR INHIBITING PIN1 BETH ISRAEL DEACONESS MEDICAL CENTER, INC. (US) 2015-09-24 WO claimed
US-20150126726-A1 COMPLEX COMPOUNDS OF GERMANIUM, METHODS FOR PRODUCING SAME, AND DRUGS OBSCHESTVO S OGRANICHENNOI OTVETSTVENNOSTYU "WDS FARMA" (RU) 2015-05-07 US claimed
EP-2851368-A1 COMPLEX COMPOUNDS OF GERMANIUM, METHODS FOR PRODUCING SAME, AND DRUGS Obschestvo S Ogranichennoi Otvetstvennostyu "WDS FARMA" (RU) 2015-03-25 EP claimed
CN-100531736-C Application of 9 - (2 - hydroxyethoxy methyl)guanine in preparing silkworm drug YUANDUO ZHOU (CN) 2009-08-26 CN claimed
EP-1594987-B1 NUCLEIC ACID SEQUENCING METHODS, KITS AND REAGENTS GENEFORM TECHNOLOGIES LTD (GB) 2009-05-27 EP claimed
CN-101091712-A Application of 9 - (2 - hydroxyethoxy methyl) in preparing silkworm drug YUANDUO ZHOU (CN) 2007-12-26 CN claimed
US-4701526-A Process for preparing 9-(2-hydroxyethoxymethyl)-guanine, and intermediates useful in said process KRKA, TOVARNA ZDRAVIL, N.SOL.O. (YU) 1987-10-20 US claimed
EP-0235931-A1 Antiviral combination THE WELLCOME FOUNDATION LIMITED (GB) 1987-09-09 EP claimed
EP-0220657-A2 Conjugate of 9-(2-hydroxyethoxymethyl)-guanine with lactosaminated human albumin, process for the peparation thereof and pharmaceutical compositions containing it LABORATORI BALDACCI Spa (IT) 1987-05-06 EP claimed
EP-0217580-A2 Therapeutic nucleosides THE WELLCOME FOUNDATION LIMITED (GB) 1987-04-08 EP claimed
US-4557934-A ALONG WITH A DIOL PYRROLIDONE OR AN AZACYCLOPENTAN-2-ONE THE PROCTER & GAMBLE COMPANY (US) 1985-12-10 US claimed
EP-0143987-A1 Therapeutic compositions endowed with antiviral activity Stendardi, Anna Gioia (IT) 1985-06-12 EP claimed
EP-0135713-A2 Antiviral combinations THE WELLCOME FOUNDATION LIMITED (GB) 1985-04-03 EP claimed
EP-0044543-B1 TOPICAL FORMULATIONS OF 9-(2-HYDROXYETHOXYMETHYL) GUANINE THE WELLCOME FOUNDATION LIMITED (GB) 1984-06-06 EP claimed
EP-0095813-A2 Penetrating topical pharmaceutical compositions containing 9-(2-hydroxyethoxymethyl) guanine THE PROCTER & GAMBLE COMPANY (US) 1983-12-07 EP claimed
US-4199574-A Methods and compositions for treating viral infections and guanine acyclic nucleosides BURROUGHS WELLCOME CO. (US) 1980-04-22 US claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20150126726-A1 COMPLEX COMPOUNDS OF GERMANIUM, METHODS FOR PRODUCING SAME, AND DRUGS GDA, ATIC, AGXT HPRT1 96/4885PNP 65/4885USP2 3730/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.