Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A11 | P48066 | 4/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | SLC6A12 | P48065 | 1/20 | 0.48 |
| ▸ | SLC6A13 | Q9NSD5 | 1/20 | 0.48 |
| ▸ | SLC6A1 | P30531 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1843791 | 0.89 | S1PR5 (0.43) | SLC6A11MEN1TP53CYP1A2CYP3A4 | |
| SCHEMBL9949505 | 0.83 | SLC6A11 (0.58) | SLC6A11MEN1TP53CYP1A2CYP3A4 | |
| SCHEMBL9949510 | 0.83 | SLC6A11 (0.58) | SLC6A11MEN1TP53CYP1A2CYP3A4 | |
| SCHEMBL2317708 | 0.82 | SLC6A1 (0.50) | SLC6A11MEN1TP53CYP1A2CYP3A4 | |
| SCHEMBL22978741 | 0.81 | SLC6A1 (0.46) | CYP1A2SLC6A1ALDH1A1 | |
| SCHEMBL740141 | 0.80 | SMN1; SMN2 (0.54) | CYP1A2SLC6A1ALDH1A1SMN1; SMN2 | |
| SCHEMBL771607 | 0.80 | SMN1; SMN2 (0.54) | CYP1A2SLC6A1ALDH1A1SMN1; SMN2 | |
| SCHEMBL1609328 | 0.80 | SMN1; SMN2 (0.54) | CYP1A2SLC6A1ALDH1A1SMN1; SMN2 | |
| SCHEMBL3841715 | 0.80 | SLC6A11 (0.55) | SLC6A11MEN1TP53CYP1A2CYP3A4 | |
| Hydrochloric Acid SCHEMBL19638092 | 0.79 | SMN1; SMN2 (0.56) | ALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2473499-A1 | BIPYRIDINES USEFUL FOR THE TREATMENT OF PROLIFERATIVE DISEASES | Novartis AG (CH) | 2012-07-11 | — | — | EP | disclosed |
| WO-2011026911-A1 | BIPYRIDINES USEFUL FOR THE TREATMENT OF PROLIFERATIVE DISEASES | NOVARTIS AG (CH) | 2011-03-10 | — | — | WO | disclosed |