Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | GLO1 | Q04760 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | SLC40A1 | Q9NP59 | 1/20 | 0.33 |
| ▸ | DRD4 | P21917 | 1/20 | 0.33 |
| ▸ | NAMPT | P43490 | 1/20 | 0.33 |
| ▸ | HTR5A | P47898 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | JAK1 | P23458 | 3/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14643938 | 0.82 | GAA (0.43) | SMN1; SMN2GAAALDH1A1PKMJAK1 | |
| SCHEMBL14643387 | 0.79 | LMNA (0.39) | SMN1; SMN2KDM4EKMT2ASLC40A1ALDH1A1 | |
| SCHEMBL204605 | 0.77 | CSNK2A1 (0.39) | SMN1; SMN2GAAALOX15HTTGLO1 | |
| SCHEMBL14644491 | 0.76 | KDM4E (0.39) | SMN1; SMN2GAAALOX15HTTKDM4E | |
| SCHEMBL14644522 | 0.74 | JAK1 (0.51) | JAK1 | |
| SCHEMBL311171 | 0.71 | KDM4E (0.41) | SMN1; SMN2ALOX15HTTKDM4EALDH1A1 | |
| SCHEMBL311312 | 0.68 | KDM4E (0.41) | SMN1; SMN2ALOX15HTTKDM4EKMT2A | |
| SCHEMBL1490778 | 0.68 | NUDT1 (0.42) | SMN1; SMN2GAAALOX15HTTKDM4E | |
| SCHEMBL18658916 | 0.68 | KDM4E (0.41) | SMN1; SMN2KDM4ENPC1TP53MAPT | |
| SCHEMBL2086309 | 0.68 | KDM4E (0.39) | SMN1; SMN2ALOX15HTTKDM4EKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013007768-A1 | TRICYCLIC HETEROCYCLIC COMPOUNDS, COMPOSITIONS AND METHODS OF USE THEREOF AS JAK INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2013-01-17 | — | — | WO | disclosed |