SCHEMBL1464415

SCHEMBL1464415

O=C(Nc1cccc(Br)n1)C1CC[S+]([O-])CC1

nearest known ligand 0.58

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HPGD P15428 1/20 0.58
SMN1; SMN2 Q16637 1/20 0.46
SLC6A2 P23975 1/20 0.42
SLC6A4 P31645 1/20 0.42
SLC6A3 Q01959 1/20 0.42
ADORA3 P0DMS8 1/20 0.41
ADORA2A P29274 1/20 0.41
ADORA2B P29275 1/20 0.41
ADORA1 P30542 1/20 0.41
CDK5 Q00535 1/20 0.41
DYRK1A Q13627 1/20 0.41
CDK5R1 Q15078 1/20 0.41
CFD P00746 4/20 0.41
NPC1 O15118 1/20 0.41
RAB9A P51151 1/20 0.41
GRM5 P41594 1/20 0.41
PLAU P00749 1/20 0.39
ABL1 P00519 1/20 0.39
GSK3B P49841 1/20 0.39
CHRNB2 P17787 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19439103 0.87 HPGD (0.77) HPGDSMN1; SMN2SLC6A2SLC6A4SLC6A3
SCHEMBL25526422 0.76 HPGD (0.55) HPGDSMN1; SMN2SLC6A2SLC6A4SLC6A3
SCHEMBL18591276 0.74 HPGD (0.53) HPGDSMN1; SMN2SLC6A2SLC6A4SLC6A3
SCHEMBL29902300 0.74 HPGD (0.53) HPGDSMN1; SMN2SLC6A2SLC6A4SLC6A3
SCHEMBL25527226 0.74 HPGD (0.56) HPGDSMN1; SMN2SLC6A2SLC6A4SLC6A3
SCHEMBL25527231 0.74 HPGD (0.56) HPGDSMN1; SMN2SLC6A2SLC6A4SLC6A3
Hydrochloric Acid SCHEMBL29545627 0.73 HPGD (0.51) HPGDSMN1; SMN2SLC6A2SLC6A4SLC6A3
Hydrochloric Acid SCHEMBL18555022 0.73 HPGD (0.51) HPGDSMN1; SMN2SLC6A2SLC6A4SLC6A3
Hydrochloric Acid SCHEMBL18555021 0.73 HPGD (0.51) HPGDSMN1; SMN2SLC6A2SLC6A4SLC6A3
Hydrochloric Acid SCHEMBL18554271 0.72 HPGD (0.50) HPGDSMN1; SMN2SLC6A2SLC6A4SLC6A3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2012101063-A1 N-ACYL PYRIDINE BIARYL COMPOUNDS AND THEIR USES NOVARTIS AG (CH) 2012-08-02 WO disclosed
EP-2473499-A1 BIPYRIDINES USEFUL FOR THE TREATMENT OF PROLIFERATIVE DISEASES Novartis AG (CH) 2012-07-11 EP disclosed
WO-2011026911-A1 BIPYRIDINES USEFUL FOR THE TREATMENT OF PROLIFERATIVE DISEASES NOVARTIS AG (CH) 2011-03-10 WO disclosed