Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 3/20 | 0.46 |
| ▸ | CTSL | P07711 | 1/20 | 0.43 |
| ▸ | CTSK | P43235 | 1/20 | 0.43 |
| ▸ | MDM4 | O15151 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.41 |
| ▸ | TLR2 | O60603 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10175069 | 1.00 | PTPN1 (0.46) | PTPN1CTSLCTSKMDM4TP53 | |
| SCHEMBL12052840 | 0.89 | PTPN1 (0.48) | PTPN1CTSLCTSKMDM4TP53 | |
| SCHEMBL8100860 | 0.89 | PTPN1 (0.48) | PTPN1CTSLCTSKMDM4TP53 | |
| SCHEMBL29047065 | 0.87 | PTPN1 (0.48) | PTPN1CTSLCTSKMDM4TP53 | |
| SCHEMBL29384797 | 0.87 | MDM4 (0.51) | PTPN1CTSLCTSKMDM4TP53 | |
| SCHEMBL29349956 | 0.87 | MDM4 (0.51) | PTPN1CTSLCTSKMDM4TP53 | |
| SCHEMBL31714182 | 0.87 | MDM4 (0.51) | PTPN1CTSLCTSKMDM4TP53 | |
| SCHEMBL29358863 | 0.87 | MDM4 (0.51) | PTPN1CTSLCTSKMDM4TP53 | |
| SCHEMBL16075059 | 0.87 | PTPN1 (0.49) | PTPN1CTSLCTSKMDM4TP53 | |
| SCHEMBL117946 | 0.87 | MDM4 (0.51) | PTPN1CTSLCTSKMDM4TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8357683-B2 | Compounds for enzyme inhibition | ONYX THERAPEUTICS, INC. (US) | 2013-01-22 | — | — | US | disclosed |