Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 1/20 | 0.48 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.47 |
| ▸ | MDM4 | O15151 | 2/20 | 0.45 |
| ▸ | TP53 | P04637 | 2/20 | 0.45 |
| ▸ | CTSL | P07711 | 1/20 | 0.44 |
| ▸ | CTSK | P43235 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8100860 | 1.00 | PTPN1 (0.48) | PTPN1MDM2MDM4TP53CTSL | |
| SCHEMBL8104883 | 0.93 | PTPN1 (0.48) | PTPN1MDM2CTSLCTSKALDH1A1 | |
| SCHEMBL12052841 | 0.93 | PTPN1 (0.48) | PTPN1MDM2CTSLCTSKALDH1A1 | |
| SCHEMBL29349956 | 0.92 | MDM4 (0.51) | PTPN1MDM2MDM4TP53CTSL | |
| SCHEMBL29047065 | 0.92 | PTPN1 (0.48) | PTPN1MDM2MDM4TP53CTSL | |
| SCHEMBL117946 | 0.92 | MDM4 (0.51) | PTPN1MDM2MDM4TP53CTSL | |
| SCHEMBL16075059 | 0.92 | PTPN1 (0.49) | PTPN1MDM2MDM4TP53CTSL | |
| SCHEMBL29384797 | 0.92 | MDM4 (0.51) | PTPN1MDM2MDM4TP53CTSL | |
| SCHEMBL119588 | 0.92 | MDM4 (0.51) | PTPN1MDM2MDM4TP53CTSL | |
| SCHEMBL31714182 | 0.92 | MDM4 (0.51) | PTPN1MDM2MDM4TP53CTSL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8080576-B2 | Compounds for enzyme inhibition | ONYX THERAPEUTICS, INC. (US) | 2011-12-20 | — | — | US | disclosed |
| US-20100144649-A1 | COMPOUNDS FOR ENZYME INHIBITION | ONYX THERAPEUTICS, INC. (US) | 2010-06-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100144649-A1 | COMPOUNDS FOR ENZYME INHIBITION | PSME1, PSMB1, PSME3 | PTPN1 1676/4885MDM2 151/4885MDM4 1727/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.