SCHEMBL14645705

SCHEMBL14645705

O=C(O)Cc1ccc(-c2noc(C(F)(F)F)n2)cc1

nearest known ligand 0.74

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
HDAC4 P56524 19/20 0.74
HDAC6 Q9UBN7 15/20 0.72
HDAC1 Q13547 2/20 0.59
HDAC8 Q9BY41 1/20 0.59
HDAC3 O15379 1/20 0.58
HDAC7 Q8WUI4 1/20 0.58
HDAC2 Q92769 1/20 0.58
HDAC5 Q9UQL6 1/20 0.58

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30882126 0.91 HDAC4 (0.69) HDAC4HDAC6HDAC1HDAC8HDAC5
SCHEMBL21581671 0.87 HDAC4 (0.72) HDAC4HDAC6HDAC1HDAC8HDAC5
SCHEMBL20640857 0.87 HDAC4 (0.76) HDAC4HDAC6HDAC1HDAC8
SCHEMBL17074132 0.86 HDAC4 (0.74) HDAC4HDAC6HDAC1HDAC8HDAC5
SCHEMBL14645419 0.85 HDAC4 (1.00) HDAC4HDAC6HDAC1HDAC8
SCHEMBL20640861 0.85 HDAC4 (0.69) HDAC4HDAC6HDAC1HDAC8HDAC5
SCHEMBL14645446 0.84 HDAC4 (1.00) HDAC4HDAC6HDAC1HDAC3HDAC7
SCHEMBL14645766 0.84 HDAC4 (0.75) HDAC4HDAC6HDAC1HDAC8
SCHEMBL21462822 0.84 HDAC4 (0.55) HDAC4HDAC6HDAC1HDAC8HDAC3
SCHEMBL14935021 0.82 HDAC4 (0.72) HDAC4HDAC6HDAC1HDAC8

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 57 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12606548-B2 Fungicidal oxadiazoles FMC CORPORATION (US) 2026-04-21 US disclosed
US-20240166638-A1 FUNGICIDAL OXADIAZOLES FMC CORP (US) 2024-05-23 US disclosed
CN-118047729-A Fungicidal oxadiazoles FMC公司 2024-05-17 CN disclosed
CN-118047771-A Fungicidal oxadiazoles FMC公司 2024-05-17 CN disclosed
EP-4361150-A2 FUNGICIDAL OXADIAZOLES AND THEIR MIXTURES FMC Corporation (US) 2024-05-01 EP disclosed
EP-3660007-B1 OXADIAZOLE COMPOUND AND FUNGICIDE FOR AGRICULTURAL AND HORTICULTURAL USE NIPPON SODA CO (JP) 2024-04-10 EP disclosed
CN-112004813-B Oxadiazole compounds for controlling phytopathogenic fungi PI工业有限公司 2024-03-29 CN disclosed
US-20240090503-A1 FUNGICIDAL OXADIAZOLES AND THEIR MIXTURES FMC CORPORATION 2024-03-21 US disclosed
CN-110650956-B Fungicidal oxadiazoles FMC公司 2024-03-08 CN disclosed
EP-4262396-A1 FUNGICIDAL OXADIAZOLES AND THEIR MIXTURES FMC CORPORATION (US) 2023-10-25 EP disclosed
WO-2017198852-A1 MICROBIOCIDAL OXADIAZOLE DERIVATIVES SYNGENTA PARTICIPATIONS AG (CH) 2017-11-23 WO disclosed
WO-2017157962-A1 MICROBIOCIDAL OXADIAZOLE DERIVATIVES SYNGENTA PARTICIPATIONS AG (CH) 2017-09-21 WO disclosed
WO-2017157962-A1 MICROBIOCIDAL OXADIAZOLE DERIVATIVES SYNGENTA PARTICIPATIONS AG (CH) 2017-09-21 WO disclosed
EP-2729454-B1 NOVEL TRIFLUOROMETHYL-OXADIAZOLE DERIVATIVES AND THEIR USE IN THE TREATMENT OF DISEASE NOVARTIS AG (CH) 2015-09-16 EP disclosed
US-9056843-B2 Trifluoromethyl-oxadiazole derivatives and their use in the treatment of disease NOVARTIS AG (CH) 2015-06-16 US disclosed
US-20140142105-A1 NOVEL TRIFLUOROMETHYL-OXADIAZOLE DERIVATIVES AND THEIR USE IN THE TREATMENT OF DISEASE NOVARTIS AG (CH) 2014-05-22 US disclosed
EP-2729454-A1 NOVEL TRIFLUOROMETHYL-OXADIAZOLE DERIVATIVES AND THEIR USE IN THE TREATMENT OF DISEASE Novartis AG (CH) 2014-05-14 EP disclosed
WO-2013066835-A2 COMPOUNDS AND METHODS GLAXOSMITHKLINE LLC (US) 2013-05-10 WO disclosed
WO-2013066835-A2 COMPOUNDS AND METHODS GLAXOSMITHKLINE LLC (US) 2013-05-10 WO disclosed
WO-2013008162-A1 NOVEL TRIFLUOROMETHYL-OXADIAZOLE DERIVATIVES AND THEIR USE IN THE TREATMENT OF DISEASE NOVARTIS AG (CH) 2013-01-17 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240166638-A1 FUNGICIDAL OXADIAZOLES OXA1L, NOX1, TH HDAC4 3224/4885HDAC6 1038/4885HDAC1 1586/4885
US-20140142105-A1 NOVEL TRIFLUOROMETHYL-OXADIAZOLE DERIVATIVES AND THEIR USE IN THE TREATMENT OF DISEASE HDAC4, HDAC5, HDAC6 HDAC4 1/4885HDAC6 3/4885HDAC1 5/4885
US-12606548-B2 Fungicidal oxadiazoles AOC2, AOC3, MT-CO3 HDAC4 3050/4885HDAC6 1102/4885HDAC1 2753/4885
US-20240090503-A1 FUNGICIDAL OXADIAZOLES AND THEIR MIXTURES NOX1, TH, NOX3 HDAC4 2535/4885HDAC6 487/4885HDAC1 888/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.