NOX3 — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL560225	1.00	2/20
Phenothiazine (SCHEMBL6532335)	1.00	2/20
SCHEMBL10372692	0.84	2/20
SCHEMBL1855582	0.83	2/20
SCHEMBL3580166	0.74	2/20
SCHEMBL11375009	0.69	2/20
SCHEMBL1926479	0.67	2/20
SCHEMBL1929116	0.67	2/20
SCHEMBL7765548	0.65	2/20
Phenothiazine (SCHEMBL9715033)	0.64	2/20
SCHEMBL4728918	0.63	2/20
SCHEMBL3582632	0.63	2/20
SCHEMBL3586107	0.62	2/20
SCHEMBL8017710	0.62	2/20
SCHEMBL1856709	0.61	2/20
SCHEMBL9671163	0.61	2/20
SCHEMBL1719191	0.61	2/20
Iodide (SCHEMBL3580170)	0.61	2/20
Phenothiazine (SCHEMBL9347283)	0.59	2/20
SCHEMBL1509893	0.59	2/20

Clinical trials — most relevant to NOX3 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Cardiotoxicity in Breast Cancer Patients	PHASE4	RECRUITING
Atorvastatin, Aspirin, Oxidative Stress, Coagulation and Platelet Activation Indexes	PHASE4	UNKNOWN
Endothelial Dysfunction and Oxidative Stress in Children With Sleep Disordered Breathing.	PHASE1/PHASE2	COMPLETED
Networked Drug REpurposing for Mechanism-based neuroPrOtection in Acute Ischaemic STROKE	PHASE2	UNKNOWN
NOX-E36 in Patients With Type 2 Diabetes Mellitus and Albuminuria	PHASE2	COMPLETED
Base Editing for Mutation Repair in Hematopoietic Stem & Progenitor Cells for X-Linked Chronic Granulomatous Disease	PHASE1/PHASE2	RECRUITING
Effect of 2-HOBA in Persistent Immune Activation in Long COVID POTS	PHASE2	RECRUITING
GKT137831 in IPF Patients With Idiopathic Pulmonary Fibrosis	PHASE2	COMPLETED
Salt-Sensitivity and Immunity Cell Activation	PHASE1/PHASE2	ACTIVE_NOT_RECRUITING
Enhancing Parasympathetic Activity to Improve Endothelial Dysfunction, Vascular Oxidative Stress in African Americans	PHASE1/PHASE2	RECRUITING
Possible Effects of Propylthiouracil, Riociguat and Perphenazine on Circulation of Healthy Volunteers	PHASE1	COMPLETED
NAC Treatment and Outcomes in Patients With Advanced Atherosclerosis and DM	PHASE1	WITHDRAWN
Effect of IFN-γ on Innate Immune Cells	PHASE1	COMPLETED
Role of NADPH Oxidase in Microvascular Dysfunction Following GDM	EARLY_PHASE1	RECRUITING
Prevalence of Sleep Apnoea in Adolescents	nan	UNKNOWN
Covid-19: Possible Role of Neutrophil Extracellular Traps	nan	UNKNOWN
NCF Gene & TNFSF4 in SLE Patients	nan	UNKNOWN
Role of Nox2 in CNI-induced Renal Fibrosis	nan	COMPLETED
Early Regenerative Intervention for Post-Traumatic Osteoarthritis	nan	UNKNOWN
Flow Mediated Dilation in Association With Hyperuricemia	nan	UNKNOWN
Effects of Nitrate-rich Beetroot Juice in Pregnant Women With High Blood Pressure	nan	UNKNOWN
Mechanisms for Individual Differences in Hypertension in Obstructive Sleep	nan	COMPLETED
Redox Determinants of Severe Asthma (a Substudy of the Severe Asthma Research Program)	nan	COMPLETED
Effect Inhaled Nitric Oxide in Adult Liver Transplant	nan	NOT_YET_RECRUITING
Antioxidants as Adjuvant Therapy to Standard Therapy in Patients With COVID-19	nan	COMPLETED
Neutrophils as Prognostic Factors in Granulomatosis With Polyangiitis (Formerly Named Wegener's Granulomatosis)	nan	COMPLETED
Oxidative Stress and Haemostasis Abnormalities in Cirrhosis	nan	UNKNOWN
Anti-inflammatory Effects of Fiber	nan	COMPLETED
HIV+ Alveolar Macrophage Oxidant-mediated Apoptosis of Pulmonary Endothelium	nan	COMPLETED
Molecular Hydrogen Inhalation: Effects on Health, Exercise Capacity and Inflammatory Response - in Vivo/in Vitro Studies	nan	NOT_YET_RECRUITING

Related proteins — ESM-2 sequence neighbours (a NOX3 binder may also engage these)

Protein	Name	Similarity
Q672K1	—	1.000	Q672K1 →
Q672J9	—	0.997	Q672J9 →
P52649	—	0.978	P52649 →
Q658P3	—	0.976	Q658P3 →
Q5RKL5	—	0.975	Q5RKL5 →
Q5R5C5	—	0.974	Q5R5C5 →
Q8CI59	—	0.973	Q8CI59 →
Q95L74	—	0.973	Q95L74 →
Q924V1	—	0.972	Q924V1 →
Q9JHI8	—	0.972	Q9JHI8 →
NOX5	NADPH oxidase 5	0.972	landscape →
NOX4	NADPH oxidase 4	0.971	landscape →
Q687X5	—	0.971	Q687X5 →
Q4V8K1	—	0.971	Q4V8K1 →
CYBB	NADPH oxidase 2	0.970	landscape →
Q9SW17	—	0.970	Q9SW17 →
Q61093	—	0.970	Q61093 →
O46522	—	0.970	O46522 →
O81209	—	0.969	O81209 →
O81210	—	0.969	O81210 →
Q923B6	—	0.968	Q923B6 →
Q2HXK9	—	0.967	Q2HXK9 →
O81211	—	0.966	O81211 →
Q9SBI0	—	0.965	Q9SBI0 →
O48538	—	0.964	O48538 →
Q9FIJ0	—	0.964	Q9FIJ0 →
A0A0R4IMY7	—	0.963	A0A0R4IMY7 →
S5UH55	—	0.962	S5UH55 →
Q8R2R1	—	0.962	Q8R2R1 →
Q948U0	—	0.962	Q948U0 →