Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP3K5 | Q99683 | 7/20 | 0.54 |
| ▸ | LRRK2 | Q5S007 | 6/20 | 0.38 |
| ▸ | CYP11B1 | P15538 | 3/20 | 0.37 |
| ▸ | CYP11B2 | P19099 | 3/20 | 0.37 |
| ▸ | APP | P05067 | 1/20 | 0.37 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.37 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.37 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.37 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.37 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.37 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.37 |
| ▸ | ABL1 | P00519 | 1/20 | 0.36 |
| ▸ | CLK1 | P49759 | 1/20 | 0.34 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1318544 | 0.82 | MAP3K5 (0.61) | MAP3K5LRRK2PIK3CDPIK3CAPIK3CB | |
| SCHEMBL3413291 | 0.82 | MAP3K5 (0.55) | MAP3K5LRRK2PIK3CDPIK3CAPIK3CB | |
| SCHEMBL12425473 | 0.79 | MAP3K5 (0.51) | MAP3K5LRRK2CYP11B1CYP11B2APP | |
| SCHEMBL3414796 | 0.78 | MAP3K5 (0.47) | MAP3K5PIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL28842738 | 0.73 | MAP3K5 (0.52) | MAP3K5LRRK2CYP11B1CYP11B2APP | |
| SCHEMBL3486191 | 0.70 | MAP3K5 (1.00) | MAP3K5CLK1 | |
| SCHEMBL14468041 | 0.68 | MAP3K5 (0.60) | MAP3K5LRRK2PIK3CDPIK3CAPIK3CB | |
| SCHEMBL1302968 | 0.67 | MAP3K5 (0.60) | MAP3K5LRRK2PIK3CDPIK3CAPIK3CB | |
| SCHEMBL3137910 | 0.67 | MAP3K5 (0.44) | MAP3K5LRRK2PIK3CDPIK3CAPIK3CB | |
| SCHEMBL16087132 | 0.67 | APP (0.46) | MAP3K5CYP11B1CYP11B2APPPIK3CG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2178373-B1 | HETEROCYCLES AS POTASSIUM CHANNEL MODULATORS | ICAGEN INC (US) | 2013-01-23 | — | — | EP | disclosed |