Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP3K5 | Q99683 | 10/20 | 0.55 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.35 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.35 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.35 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.35 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.35 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.35 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.35 |
| ▸ | ABL1 | P00519 | 2/20 | 0.34 |
| ▸ | METTL3 | Q86U44 | 2/20 | 0.34 |
| ▸ | CLK2 | P49760 | 1/20 | 0.33 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.33 |
| ▸ | RET | P07949 | 1/20 | 0.33 |
| ▸ | CDK2 | P24941 | 1/20 | 0.33 |
| ▸ | GSK3B | P49841 | 1/20 | 0.33 |
| ▸ | ITK | Q08881 | 1/20 | 0.33 |
| ▸ | MERTK | Q12866 | 1/20 | 0.33 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.33 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.33 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL253485 | 0.84 | MAP3K5 (0.61) | MAP3K5MCHR1PIK3CAPIK3CDPIK3CB | |
| SCHEMBL14647252 | 0.82 | MAP3K5 (0.54) | MAP3K5PIK3CAPIK3CDPIK3CBPIK3CG | |
| SCHEMBL3414796 | 0.74 | MAP3K5 (0.47) | MAP3K5PIK3CAPIK3CDPIK3CBPIK3CG | |
| SCHEMBL3486067 | 0.71 | MAP3K5 (1.00) | MAP3K5CLK2RETCDK2GSK3B | |
| SCHEMBL8829997 | 0.66 | MAP3K5 (0.47) | MAP3K5MCHR1METTL3 | |
| SCHEMBL18727768 | 0.66 | MAP3K5 (0.44) | MAP3K5PIK3CGMETTL3 | |
| SCHEMBL1318544 | 0.65 | MAP3K5 (0.61) | MAP3K5PIK3CAPIK3CDPIK3CBPIK3CG | |
| SCHEMBL14468041 | 0.65 | MAP3K5 (0.60) | MAP3K5MCHR1PIK3CAPIK3CDPIK3CB | |
| SCHEMBL22528949 | 0.64 | METTL3 (0.44) | MAP3K5MCHR1METTL3 | |
| SCHEMBL2249756 | 0.64 | METTL3 (0.44) | MAP3K5MCHR1ABL1METTL3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012003338-A1 | COMBINATION OF A cMET INHIBITOR AND AN ANTIBODY TO HGF AND/OR cMET | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-01-05 | — | — | WO | disclosed |