Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP3K5 | Q99683 | 13/20 | 0.47 |
| ▸ | RAB9A | P51151 | 4/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | NPC1 | O15118 | 3/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.46 |
| ▸ | GLA | P06280 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | ALDH1A3 | P47895 | 1/20 | 0.43 |
| ▸ | RET | P07949 | 2/20 | 0.41 |
| ▸ | CDK2 | P24941 | 2/20 | 0.41 |
| ▸ | GSK3B | P49841 | 2/20 | 0.41 |
| ▸ | ITK | Q08881 | 2/20 | 0.41 |
| ▸ | MERTK | Q12866 | 2/20 | 0.41 |
| ▸ | PRKAA1 | Q13131 | 2/20 | 0.41 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.41 |
| ▸ | MAP3K6 | O95382 | 2/20 | 0.41 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.39 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.39 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL251221 | 0.88 | MAP3K5 (0.49) | MAP3K5RAB9AALDH1A1NPC1KDM4E | |
| SCHEMBL14647252 | 0.78 | MAP3K5 (0.54) | MAP3K5PIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL3413291 | 0.74 | MAP3K5 (0.55) | MAP3K5RETCDK2GSK3BITK | |
| SCHEMBL7274569 | 0.73 | KDM4E (0.56) | MAP3K5RAB9AALDH1A1NPC1KDM4E | |
| SCHEMBL408219 | 0.72 | RAB9A (0.56) | MAP3K5RAB9AALDH1A1NPC1KDM4E | |
| SCHEMBL17643979 | 0.72 | RAB9A (0.47) | MAP3K5RAB9AALDH1A1NPC1KDM4E | |
| SCHEMBL18065871 | 0.72 | RAB9A (0.61) | RAB9AALDH1A1NPC1KDM4EGLA | |
| SCHEMBL5327076 | 0.72 | KDM4E (0.55) | MAP3K5RAB9AALDH1A1NPC1KDM4E | |
| SCHEMBL3301442 | 0.72 | RAB9A (0.55) | MAP3K5RAB9AALDH1A1NPC1KDM4E | |
| SCHEMBL3486260 | 0.72 | MAP3K5 (0.56) | MAP3K5ALDH1A1ALDH1A3RETCDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012003338-A1 | COMBINATION OF A cMET INHIBITOR AND AN ANTIBODY TO HGF AND/OR cMET | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-01-05 | — | — | WO | disclosed |